Practical Approaches to the Use of Lenalidomide in Multiple Myeloma: A Canadian Consensus

Table 4

Lenalidomide dose adjustment for thrombocytopenia.

Platelet count	Recommendations
<30 × 10^9/L on day 1 of a cycle	Delay start of the cycle for a week, until platelet count ≥30 × 10^9/L
<30 × 10^9/L during a cycle	Interruption of lenalidomide until next cycle (dexamethasone should be continued)
Returning to ≥30 × 10^9/L on next cycle	Reduce lenalidomide to the first reduction level
For each subsequent drop <30 × 10^9/L	Interrupt lenalidomide treatment
Returning to ≥30 × 10^9/L on next cycle	Resume lenalidomide at next dose reduction level