Practical Approaches to the Use of Lenalidomide in Multiple Myeloma: A Canadian Consensus

Table 7

Management of rashes due to lenalidomide.

Signs/symptoms	Treatment
Localized maculopapular rash	Topical steroids; antihistamines
Widespread maculopapular rash	Hold lenalidomide; topical or oral steroids depending on severity; antihistamines; after resolution, restart lenalidomide at lower dose
Generalize erythroderma or desquamation	Hold lenalidomide; oral steroids; Dermatology consultation; do not restart lenalidomide
Urticaria	Hold lenalidomide; symptomatic management with antihistamines ± oral steroids; after resolution, may attempt desensitization if reinitiation of lenalidomide is planned