Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models

Figure 1

A schematic of overall view of zebrafish hematopoiesis with shifting sites, types of cells produced at each site, and genes involved, shown in 3 tiers as described below. Tier 1: lineage-specific transcription factors that control primitive and definitive hematopoiesis in zebrafish. Tier 2: the sites of action during each stage of hematopoiesis and the types of cells produced at each of the sites. The site boxes are color matched with waves of hematopoiesis and temporally placed according to the developmental stages in Tier 3. Tier 3: the time scale depicting the stage of development in hpf (hours postfertilization) and dpf (days postfertilization) and different waves of hematopoiesis. The abbreviations used are as follows: ALM: anterior lateral mesoderm, PLM: posterior lateral mesoderm, PBI: posterior blood island, AGM: aorta-gonad-mesonephros, CHT: caudal hematopoietic tissue, PM: primitive macrophages, PE: primitive erythrocytes, HSCs: hematopoietic stem cells, TD: transient definitive wave.