Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models

Table 1

Lineage-specific mutant and transgenic lines for zebrafish hematopoiesis research.

Lineage	Marker	Mutant lines		Transgenic lines
		Mutant designation and mutation type	References	Line designation	References
Hemangioblast	tal1/scl	t21384, K183X	[38]	PAC-tal1:GFP 5.0tal1:EGFP	[39, 40]
	lmo2	None		lmo2:EGFP lmo2:DsRed	[41]
EMPs	runx1	hg1, W84X	[42, 43]	runx1P1:EGFP	[44]
	runx1	hg1, W84X	[42, 43]	runx1P2:EGFP	[44]
HSCs	cmyb	t25217, I181N; hkz3, truncation in transactivation domain	[45]; [46]	cmyb:EGFP	Developed by the Zon lab, used in [47]
	cd41	None		cd41:GFP	[33, 34]
Erythropoiesis	gata1	m651 (vlad tepes), R339X; hg2, T301K	[23]; [48]	gata1:GFP gata1:DsRed	[37, 49]
Myelopoiesis: GMPs	spi1/pu.1	None		spi1:EGFP zpu.1:EGFP	[50, 51]
	mpx	None		mpx:GFP	[52]
Myelopoiesis: Neutrophils, Macrophages, Monocytes	lyz	None		lyz:EGFP lyz:DsRed	[53]
	mpeg1	None		mpeg1:EGFP mpeg1:mCherry	[54]
	rag1	t26683, R797X	[55]	rag1:GFP	[56]
Lymphopoiesis	lck	None		lck:EGFP	[57]
	ikzf1/ikaros	t24980, Q360X	[58]	ikzf1:GFP	[59]