PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
Schematic structures of AKT1 (a) and PTEN (b) protein. The predicted consensual domain structures for each protein are depicted. PH domain: pleckstrin homology domain; C2 domain: a protein structural domain involved in targeting proteins to cell membranes; PDZ: a common structural domain in signaling proteins (PSD95, Dlg, ZO-1, etc.).
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