695754.fig.002a
(a)
695754.fig.002b
(b)
Figure 2: miRNA mediated translation repression. (a) At initiation stage the miRNP (miRNA ribonucleoprotein complex) impairs the recognition of cap by eIF4E there by inhibiting the recruitment of ribosomal subunits onto the mRNA. (b) miRNA mediated degradation of mRNA by deadenylation of 3′−5′ exonuclease after recruiting CCR4-NOT to the polyadenylation site where GW182 is required to bind to miRNPs. Replacement of cap by decapping enzymes DCP1/2 hampers the translation initiation.