MicroRNAs as Haematopoiesis Regulators

Table 4

miRNA involved in megakaryopoiesis.

miRNA	Function	Putative targets	Reference
miR-34a	MK differentiation of K562 cells, targets cMyb, CDKs, and MEK1	HMGN4, CCDC52, KLRK1, RGS17, NFATCG	[42, 43]
miR-155	Downregulated in megakaryopoiesis, targets Meis-1 and Ets-1	MMP16, SLC11A2, C2orf18	[44]
miR-146a, miR-145	Involved in megakaryopoiesis by activating innate immunity and mediates 5q syndrome phenotype	SOX11, SP1	[45]
miR-146a	Increased in MK development and targets CXCR4	CREBL2, NOTCH2, TRAK2, TBX18, RIN2, RAD23B, SLC1A2	[46, 47]
miR-150	Favours megakaryocyte lineage differentiation; it targets cMyb, induced by TPO	SLC24A4	[47, 48]
miR-28	It targets TPO receptor and prevents MK differentiation from CD34^+ cells		[49]
miR-27a	miR-27a targets and decrease RUNX1 levels	TRIM9, CYB5B, EGR2, BASP1	[50]
miR-181a	miR-181a inhibit Ca2^+ induced differentiation of MKs		[51]
miR-125b-2	Induces proliferation and differentiation of MKs	RAD98, ZNF100, PDS5B, SHE, CDR2	[52]
miR-181	Mediates MK differentiation by disrupting LIN28/let-7 axis	FOXP1, CCN8, HOXA1	[53]