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Advances in Hematology
Volume 2013 (2013), Article ID 949513, 16 pages
http://dx.doi.org/10.1155/2013/949513
Review Article

Dendritic Cell Development: A Choose-Your-Own-Adventure Story

1Division of Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
2Department of Immunology, University of Toronto, Toronto, ON, Canada M5S 1A8

Received 5 November 2012; Accepted 27 December 2012

Academic Editor: Sheila Dias

Copyright © 2013 Amanda J. Moore and Michele K. Anderson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dendritic cells (DCs) are essential components of the immune system and contribute to immune responses by activating or tolerizing T cells. DCs comprise a heterogeneous mixture of subsets that are located throughout the body and possess distinct and specialized functions. Although numerous defined precursors from the bone marrow and spleen have been identified, emerging data in the field suggests many alternative routes of DC differentiation from precursors with multilineage potential. Here, we discuss how the combinatorial expression of transcription factors can promote one DC lineage over another as well as the integration of cytokine signaling in this process.