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Advances in Hematology
Volume 2014, Article ID 103175, 15 pages
http://dx.doi.org/10.1155/2014/103175
Review Article

The Epigenetic Landscape of Acute Myeloid Leukemia

Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK

Received 25 October 2013; Revised 27 January 2014; Accepted 3 February 2014; Published 23 March 2014

Academic Editor: Myriam Labopin

Copyright © 2014 Emma Conway O’Brien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [50 citations]

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  • Ian A MacDonald, and Nathaniel A Hathaway, “Epigenetic roots of immunologic disease and new methods for examining chromatin regulatory pathways,” Immunology and Cell Biology, 2014. View at Publisher · View at Google Scholar
  • Parinaz Mehdipour, Fabio Santoro, and Saverio Minucci, “Epigenetic alterations in acute myeloid leukemias,” FEBS Journal, 2014. View at Publisher · View at Google Scholar
  • Nicolas Duployez, Christophe Willekens, Alice Marceau-Renaut, Elise Boudry-Labis, and Claude Preudhomme, “Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors,” Expert Review of Hematology, pp. 1–14, 2014. View at Publisher · View at Google Scholar
  • Bian-Hong Wang, Yong-Hui Li, and Li Yu, “Genomics-based Approach and Prognostic Stratification Significance of Gene Mutations in Intermediate-risk Acute Myeloid Leukemia,” Chinese Medical Journal, vol. 128, no. 17, pp. 2395–2403, 2015. View at Publisher · View at Google Scholar
  • Meifeng Zhou, and Xiuzhen Tong, “Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia,” Diagnostic Pathology, vol. 10, 2015. View at Publisher · View at Google Scholar
  • Behzad Kharabi Masouleh, Eric Chevet, Jens Panse, Edgar Jost, Michael O’Dwyer, Tim H. Bruemmendorf, and Afshin Samali, “Drugging the unfolded protein response in acute leukemias,” Journal of Hematology & Oncology, vol. 8, no. 1, 2015. View at Publisher · View at Google Scholar
  • Tae Kon Kim, Steven D. Gore, and Amer M. Zeidan, “Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions,” Seminars in Hematology, vol. 52, no. 3, pp. 172–183, 2015. View at Publisher · View at Google Scholar
  • Anna Eriksson, Andreas Lennartsson, and Sören Lehmann, “Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis,” Experimental Hematology, 2015. View at Publisher · View at Google Scholar
  • Zhongwu Zhou, II-Hood Cho, Zhi Shan, and Joseph Irudayaraj, “Cross-platform detection of epigenetic modifications from extracted chromatin in leucocytes from blood,” Analytical Chemistry Research, vol. 4, pp. 39–44, 2015. View at Publisher · View at Google Scholar
  • Dennis J. Goussetis, and Leonidas C. Platanias, “Synergism between arsenic trioxide and aclacinomycin in acute myeloid leukemia,” Leukemia & Lymphoma, pp. 1–2, 2015. View at Publisher · View at Google Scholar
  • Sang Hyuk Park, Hawk Kim, Moo-Kon Song, Joo Seop Chung, Ho-Jin Shin, Hyun Ji Lee, In-Suk Kim, Jeong-Eun Kang, Eun Yup Lee, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Jong-Ho Won, and Soo Mee Bang, “Incidences and prognostic impact of c-KIT, WT1, CEBPA, and CBL mutations, and mutations associated with epigenetic modification in core binding factor acute myeloid leukemia: A multicenter study in a Korean population,” Annals of Laboratory Medicine, vol. 35, no. 3, pp. 288–297, 2015. View at Publisher · View at Google Scholar
  • Aparna Vasanthakumar, and Lucy A. Godley, “5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy,” Cancer Genetics, vol. 208, no. 5, pp. 167–177, 2015. View at Publisher · View at Google Scholar
  • Håkon Reikvam, Tuyen Thi van Hoang, and Øystein Bruserud, “Emerging therapeutic targets in human acute myeloid leukemia (part 2) – bromodomain inhibition should be considered as a possible strategy for various patient subsets,” Expert Review of Hematology, pp. 1–13, 2015. View at Publisher · View at Google Scholar
  • Helen J. S. Stewart, Ella Shalit, Loryn Halliday, Dominic Morey, and Timothy J. Chevassut, “Acute myeloid leukemia cells exhibit selective down-regulation of DNMT3A isoform 2,” Leukemia & Lymphoma, vol. 56, no. 12, pp. 3445–3448, 2015. View at Publisher · View at Google Scholar
  • Christian Cremer, Hanna Braun, Radoslav Mladenov, Lea Schenke, Xiaojing Cong, Edgar Jost, Tim H. Bruemmendorf, Rainer Fischer, Paolo Carloni, Stefan Barth, and Thomas Nachreiner, “Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo,” Cancer Immunology Immunotherapy, vol. 64, no. 12, pp. 1575–1586, 2015. View at Publisher · View at Google Scholar
  • Niccolo Bolli, and George Vassilioupp. 314–331, 2015. View at Publisher · View at Google Scholar
  • Brittany A. Woods, and Ross L. Levine, “The role of mutations in epigenetic regulators in myeloid malignancies,” Immunological Reviews, vol. 263, no. 1, pp. 22–35, 2015. View at Publisher · View at Google Scholar
  • Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Shao-Yan Hu, Fang Fang, Lan Cao, Pei-Fang Xiao, Xiao-Juan Du, Li-Chao Sun, Zhi-Heng Li, Na-Na Wang, Guang-Hao Su, Yan-Hong Li, Gang Li, He Zhao, Yi-Ping Li, Yun-Yun Xu, Hui-Ting Zhou, Yi Wu, Mei-Fang Jin, Lin Liu, Xue-Ming Zhu, Jian Ni, Jian Wang, Feng Xing, Wen-Li Zhao, and Jian Pan, “Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia,” Journal of Experimental & Clinical Cancer Research, vol. 34, no. 1, 2015. View at Publisher · View at Google Scholar
  • Viren Amin, Vitor Onuchic, and Aleksandar Milosavljevic, “Mining the Epigenetic Landscape,” Epigenetic Cancer Therapy, pp. 141–165, 2015. View at Publisher · View at Google Scholar
  • Eiman Aleem, and Robert J Arceci, “Targeting cell cycle regulators in hematologic malignancies.,” Frontiers in cell and developmental biology, vol. 3, pp. 16, 2015. View at Publisher · View at Google Scholar
  • Sureshkumar Raveendran, Santhi Sarojam, Sangeetha Vijay, Aswathy Chandran Geetha, Jayadevan Sreedharan, Geetha Narayanan, and Hariharan Sreedharan, “Mutation analysis of IDH1/2 genes in unselected de novo acute myeloid Leukaemia Patients in India - identification of a novel IDH2 mutation,” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 9, pp. 4095–4101, 2015. View at Publisher · View at Google Scholar
  • Xiaowu Zhong, Yuanhong Peng, Chengjiao Yao, Yufeng Qing, Qibin Yang, Xiaolan Guo, Wenguang Xie, Mingcai Zhao, Xiaoming Cai, and Jing-Guo Zhou, “Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis,” Biomedical Reports, vol. 5, no. 4, pp. 467–472, 2016. View at Publisher · View at Google Scholar
  • Lacramioara Botezatu, Judith Schütte, Bernd Giebel, Michael Heuser, Jaroslaw Maciejewski, Cyrus Khandanpour, Anne Helness, François Robert, Lothar Vassen, Yahya Al-Matary, Robert F. Lams, André Görgens, Hind Medyouf, Ulrich Dührsen, Tarik Möröy, Lars C. Michel, Charles Vadnais, Hideki Makishima, Judith M. Hönes, and Aniththa Thivakaran, “Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML,” Experimental Hematology, vol. 44, no. 8, pp. 713–726.e14, 2016. View at Publisher · View at Google Scholar
  • Nicolas Duployez, Martin Figeac, Karine Celli-Lebras, Catherine Lacombe, Jean-Baptiste Micol, Omar Abdel-Wahab, Pascale Cornillet, Norbert Ifrah, Hervé Dombret, Guy Leverger, Eric Jourdan, Alice Marceau-Renaut, Claude Preudhomme, Nicolas Boissel, Arnaud Petit, Maxime Bucci, Sandrine Geffroy, Hélène Lapillonne, Aline Renneville, and Christine Ragu, “Comprehensive mutational profiling of core binding factor acute myeloid leukemia,” Blood, vol. 127, no. 20, pp. 2451–2459, 2016. View at Publisher · View at Google Scholar
  • Qingxiao Hong, Yirun Li, Xiaoying Chen, Huadan Ye, Linlin Tang, Annan Zhou, Yan Hu, Yuting Gao, Rongrong Chen, Yongming Xia, and Shiwei Duan, “CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy,” Experimental And Therapeutic Medicine, vol. 11, no. 5, pp. 1901–1907, 2016. View at Publisher · View at Google Scholar
  • Abhishek Mangaonkar, Ravindra Kolhe, Hongyan Xu, Jamal Mohsin, Joshua Mansour, Amber B. Clemmons, Stephen M. Clark, Arpita Shah, Anand Jillela, Vamsi Kota, Rohini Chintalapally, Ryan Keen, Ashis K. Mondal, and David DeRemer, “Prognostic value of complete remission with superior platelet counts in acute myeloid leukemia,” Journal of Community and Supportive Oncology, vol. 14, no. 2, pp. 66–71, 2016. View at Publisher · View at Google Scholar
  • Ranjani Ramamurthy, Maya Hughes, Valerie Morris, Hamid Bolouri, Robert B. Gerbing, Michael R. Loken, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Vivian G. Oehler, Todd A. Alonzo, Soheil Meshinchi, and Yi-Cheng Wang, “miR-155 expression and correlation with clinical outcome in pediatric AML: A report from Children's Oncology Group,” Pediatric Blood and Cancer, vol. 63, no. 12, pp. 2096–2103, 2016. View at Publisher · View at Google Scholar
  • Norbert Vey, Thomas Prebet, Claire Thalamas, Aude Charbonnier, Jerome Rey, Ioana Kloos, Emily Liu, Ying Luan, Remus Vezan, Thorsten Graef, and Christian Recher, “Phase 1 dose-escalation study of oral abexinostat for the treatment of patients with relapsed/refractory higher-risk myelodysplastic syndromes, acute myeloid leukemia, or acute lymphoblastic leukemia,” Leukemia & Lymphoma, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Maximilian Stahl, Nathan Kohrman, Steven D. Gore, Amer M. Zeidan, Tae Kon Kim, and Thomas Prebet, “Epigenetics in Cancer: A Hematological Perspective,” PLoS Genetics, vol. 12, no. 10, 2016. View at Publisher · View at Google Scholar
  • Adam P. Deveau, Victoria L. Bentley, and Jason N. Berman, “Using zebrafish models of leukemia to streamline drug screening and discovery,” Experimental Hematology, 2016. View at Publisher · View at Google Scholar
  • Jae-Sook Ahn, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Dennis Dong Hwan Kim, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Seun-Shin Lee, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Nan Young Kim, and Seung Hyun Choi, “DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation,” Biology of Blood and Marrow Transplantation, vol. 22, no. 1, pp. 61–70, 2016. View at Publisher · View at Google Scholar
  • C. Giorgio, C. Dell’Aversana, and L. Altucci, “Epigenetics in Acute Myeloid Leukemia,” Medical Epigenetics, pp. 483–498, 2016. View at Publisher · View at Google Scholar
  • Jin-Li Wen, Ning Li, Yong Dai, Xiao-Cong Lin, Yong Xu, Guo-Ping Sun, Yu-Ming Zhang, Zhi-Gang Yang, and Hai-Tao Zhang, “Molecular dysfunctions in acute myeloid leukemia revealed by integrated analysis of microRNA and transcription factor,” International Journal of Oncology, vol. 48, no. 6, pp. 2367–2380, 2016. View at Publisher · View at Google Scholar
  • Peter T. Saunders, “Epigenetics and Evolution,” Human Development, vol. 60, no. 2-3, pp. 81–94, 2017. View at Publisher · View at Google Scholar
  • Xiaoping Cai, Yigai Ma, Fang Liu, Ming Gong, Li Gao, and Hui Zhang, “RASSFIA hypermethylation is associated with ASXLI mutation and indicates an adverse outcome in non-M3 acute myeloid leukemia,” OncoTargets and Therapy, vol. 10, pp. 4135–4151, 2017. View at Publisher · View at Google Scholar
  • Xia Xiao, Yan Sun, Rui Li, Qian Xu, Ziwei Lu, Xinxin Wang, Xin Jiang, Guirong Zhang, and Yechen Xiao, “5-aza-2′-deoxycytidine promotes migration of acute monocytic leukemia cells via activation of CCL2-CCR2-ERK signaling pathway,” Molecular Medicine Reports, vol. 16, no. 2, pp. 1417–1424, 2017. View at Publisher · View at Google Scholar
  • Yordan Sbirkov, Colin Kwok, Amandeep Bhamra, Andrew Thompson, Veronica Gil, Arthur Zelent, and Kevin Petrie, “Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase,” International Journal of Molecular Sciences, vol. 18, no. 7, pp. 1440, 2017. View at Publisher · View at Google Scholar
  • Giulia Daniele, Hilmar Quentmeier, Orazio Palumbo, Massimo Carella, Margherita Perricone, Emanuela Ottaviani, Giorgia Simonetti, Carmen Baldazzi, Nicoletta Testoni, Cristina Papayannidis, Sergio Ferrari, Clelia Tiziana Storlazzi, Caterina Fusilli, Antonio Palazzo, Fabiana Mammoli, Renè Massimiliano Marsano, Elena Marasco, Vilma Mantovani, Hans G. Drexler, Jie Ding, Niroshan Nadarajah, Tommaso Mazza, Giovanni Martinelli, Ilaria Iacobucci, Angelo Lonoce, and Mariana Lomiento, “Epigenetically induced ectopic expression of uncx impairs the proliferation and differentiation of myeloid cells,” Haematologica, vol. 102, no. 7, pp. 1204–1214, 2017. View at Publisher · View at Google Scholar
  • Olga K. Weinberg, Aliyah R. Sohani, Valentina Nardi, and Parul Bhargava, “Diagnostic work-up of acute myeloid leukemia,” American Journal of Hematology, vol. 92, no. 3, pp. 317–321, 2017. View at Publisher · View at Google Scholar
  • Medeiros, DiNardo, Pollyea, Chan, Swords, and Fathi, “Isocitrate dehydrogenase mutations in myeloid malignancies,” Leukemia, vol. 31, no. 2, pp. 272–281, 2017. View at Publisher · View at Google Scholar
  • Preethi Kunchala, Sudhakiranmayi Kuravi, Roy Jensen, Joseph McGuirk, and Ramesh Balusu, “When the good go bad: Mutant NPM1 in acute myeloid leukemia,” Blood Reviews, 2017. View at Publisher · View at Google Scholar
  • Geoffrey Brown, and Ewa Marcinkowska, “Acute Myeloid Leukaemia: New Targets and Therapies,” International Journal of Molecular Sciences, vol. 18, no. 12, pp. 2577, 2017. View at Publisher · View at Google Scholar
  • Jae-Sook Ahn, Seung Hyun Choi, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Szardenings Michael, Mark D. Minden, Hyeoung-Joon Kim, Dennis Dong Hwan Kim, Yeo-Kyeoung Kim, Seung-Shin Lee, Seo- Yeon Ahn, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, and Hee Jeong Park, “5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia,” Oncotarget, vol. 8, no. 5, pp. 8305–8314, 2017. View at Publisher · View at Google Scholar
  • Mengning Wang, Chuanwei Yang, Le Zhang, and Dale G. Schaar, “Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia,” Stem Cells International, vol. 2017, pp. 1–11, 2017. View at Publisher · View at Google Scholar
  • Melis Karabulutoglu, Rosemary Finnon, Tatsuhiko Imaoka, Anna A. Friedl, and Christophe Badie, “Influence of diet and metabolism on hematopoietic stem cells and leukemia development following ionizing radiation exposure,” International Journal of Radiation Biology, pp. 1–27, 2018. View at Publisher · View at Google Scholar
  • Aylin Camgoz, Maciej Paszkowski-Rogacz, Martin V. Hamann, Chunaram Choudhary, Stefan Knapp, Frank Buchholz, Shankha Satpathy, Martin Wermke, and Malte von Bonin, “STK3 is a therapeutic target for a subset of acute myeloid leukemias,” Oncotarget, vol. 9, no. 39, pp. 25458–25473, 2018. View at Publisher · View at Google Scholar
  • Rafael Bejar, “What biologic factors predict for transformation to AML?,” Best Practice and Research: Clinical Haematology, vol. 31, no. 4, pp. 341–345, 2018. View at Publisher · View at Google Scholar
  • Kebede Begna, Mythri Mudireddy, Rangit Vallapureddy, Nelson Leung, Lance Pagliaro, Tamas Ordog, Niraj Shenoy, Mrinal Patnaik, R. Houston Thompson, Ayalew Tefferi, Thomas Witzig, Fang-Shu Ou, and John Cheville, “Association Between Renal Cell Carcinoma and Myelodysplastic Syndromes: Epigenetic Underpinning?,” Clinical Genitourinary Cancer, vol. 16, no. 6, pp. e1117–e1122, 2018. View at Publisher · View at Google Scholar
  • Kerri Becktell, Kerri Houser, and Michael J. Burke, “Epigenetic Therapy in a Patient With Down Syndrome and Refractory Acute Myeloid Leukemia,” Journal of Pediatric Hematology/Oncology, vol. 41, no. 1, pp. e38–e40, 2019. View at Publisher · View at Google Scholar
  • Aksinija A. Kogan, Rena G. Lapidus, Maria R. Baer, and Feyruz V. Rassool, “Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow microenvironment,” 2019. View at Publisher · View at Google Scholar