Frequency and Prognostic Relevance of FLT3 Mutations in Saudi Acute Myeloid Leukemia Patients

Figure 1

Diagram of FLT3 structure. Shown in schematic fashion are the 5 immunoglobulin-like folds that make up the ligand-binding extracellular domain, single transmembrane domain, and cytoplasmic domain made up of a kinase domain interrupted by a kinase insert. The juxtamembrane domain where internal tandem duplications (ITDs) occur and aspartic acid 835 where most kinase domain mutations occur are indicated by arrows (Small D. FLT3 Mutations: Biology and Treatment. Hematology Am Soc Hematol Educ Program. 2006).