Research Article

Frequency and Prognostic Relevance of FLT3 Mutations in Saudi Acute Myeloid Leukemia Patients

Table 1

Summary of the characteristics of the patients included in the study.

ParameterFLT3-mutated patients ( )FLT3 WT patients ( )

Male : female13 : 534 : 45
Median age (years)3835
Median WBCs count65 × 109/L12.5 × 109/L
Median platelets count53 × 109/L71 × 109/L
Median hemoglobin9.1 g/dL10 g/dL
Median PB blasts 40%8%
History of AML
 De novo AML18/9476/94
 Secondary s-AML0/33/3
FLT3 mutation rate and OS
FLT3-ITD14/97 (14.43%)NA
FLT3-D8354/97 (4.12%)NA
 Total18/97 (18.55%)NA
 Median OS (months)1020
Cytogeneticanalysis
 Available for FISH1856
 Available for karyotype1340
 t (8; 21)16
 t (15; 17)13
 inv 16/t (16; 16)13
 11q23/MLL12
 Non recurrent translocations 05
 +825
 +511
 +1302
 +2101
 −801
 5q−/−5 0 2
7q−/−702
Complex karyotype02
Hyperdiploid02
Other aberrations04

WT: wild type; OS: overall survival; FISH: fluorescence in situ hybridization.