Table of Contents Author Guidelines Submit a Manuscript
Advances in Hematology
Volume 2014, Article ID 470242, 7 pages
http://dx.doi.org/10.1155/2014/470242
Research Article

RhD Specific Antibodies Are Not Detectable in HLA-DRB1 Mice Challenged with Human RhD Positive Erythrocytes

1The Canadian Blood Services, Canada
2Department of Laboratory Medicine and the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8
3Immunohematology Reference Laboratory, BloodCenter of Wisconsin, Milwaukee, WI 53226, USA
4Department of Transfusion Medicine, St. Michael’s Hospital, Toronto, ON, Canada M5B 1W8
5Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada

Received 7 November 2014; Revised 15 December 2014; Accepted 16 December 2014; Published 31 December 2014

Academic Editor: Thomas Kickler

Copyright © 2014 Lidice Bernardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Hall, L. S. Cairns, D. M. Altmann, R. N. Barker, and S. J. Urbaniak, “Immune responses and tolerance to the RhD blood group protein in HLA-transgenic mice,” Blood, vol. 105, no. 5, pp. 2175–2179, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L.-M. Stott, R. N. Barker, and S. J. Urbaniak, “Identification of alloreactive T-cell epitopes on the Rhesus D protein,” Blood, vol. 96, no. 13, pp. 4011–4019, 2000. View at Google Scholar · View at Scopus
  3. S. J. Urbaniak, “Alloimmunity to human red blood cell antigens,” Vox Sanguinis, vol. 83, supplement s1, pp. 293–297, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Khare, A. Mangalam, M. Rodriguez, and C. S. David, “HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice,” Journal of Neuroimmunology, vol. 169, no. 1-2, pp. 1–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. C. L. van Kim, I. Mouro, B. Cherif-Zahar et al., “Molecular cloning and primary structure of the human blood group RhD polypeptide,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 22, pp. 10925–10929, 1992. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Freedman and A. H. Lazarus, “Applications of flow cytometry in transfusion medicine,” Transfusion Medicine Reviews, vol. 9, no. 2, pp. 87–109, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Yalcin, J. Nicod, A. Bhomra et al., “Commercially available outbred mice for genome-wide association studies,” PLoS Genetics, vol. 6, no. 9, Article ID e1001085, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. Liu and C. H. Huang, “The mouse Rhl1 and Rhag genes: Sequence, organization, expression, and chromosomal mapping,” Biochemical Genetics, vol. 37, no. 3-4, pp. 119–138, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. C. M. Westhoff, “The structure and function of the Rh antigen complex,” Seminars in Hematology, vol. 44, no. 1, pp. 42–50, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Simsek, C. A. de Jong, H. T. Cuijpers et al., “Sequence analysis of cDNA derived from reticulocyte mRNAs coding for Rh polypeptides and demonstration of E/e and C/c polymorphisms,” Vox Sanguinis, vol. 67, no. 2, pp. 203–209, 1994. View at Publisher · View at Google Scholar
  11. W. A. Flegel, “Molecular genetics of RH and its clinical application,” Transfusion Clinique et Biologique, vol. 13, no. 1-2, pp. 4–12, 2006. View at Google Scholar
  12. H. Zola, “High-sensitivity immunofluorescence/flow cytometry: detection of cytokine receptors and other low-abundance membrane molecules,” in Current Protocols in Cytometry, Chapter 6: Unit 3, 2004. View at Publisher · View at Google Scholar
  13. M. A. Arce, E. S. Thompson, S. Wagner, K. E. Coyne, B. A. Ferdman, and D. M. Lublin, “Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals,” Blood, vol. 82, no. 2, pp. 651–655, 1993. View at Google Scholar · View at Scopus