Therapy with Interleukin-22 Alleviates Hepatic Injury and Hemostasis Dysregulation in Rat Model of Acute Liver Failure
Figure 1
Hepatoprotective effect of IL-22 therapy against D-GalN/LPS-induced acute liver injury in rats. In comparison with livers of normal control rats (a), after 48 h from injection of D-GalN/LPS, there was severe hepatic injury that reflected a high degree of hepatocellular necrosis, apoptosis, and inflammatory cell infiltration (b); however, livers of rats injected with D-GalN/LPS and then treated with IL-22 (c) showed scant pathological foci and undetectable inflammatory cell infiltration.
