Persistent Polyclonal B Cell Lymphocytosis B Cells Can Be Activated through CD40-CD154 Interaction

Figure 5

Isotype switching during culture of PPBL B cells with low CD154 interaction. The IgG and IgM secretion ratios of PPBL CD19⁺ cells stimulated with a low level of CD154 interaction were determined by ELISA in supernatant collected after 5 days (5 d) and evaluated on day 14 (14 d), for all patient samples. Four healthy controls submitted to identical culture conditions (HC) were analyzed similarly and data is presented as the mean ± SD.