Review Article

Autologous Graft-versus-Tumor Effect: Reality or Fiction?

Table 2

Autograft immune effector cells and survival after autologous hematopoietic stem cell transplantation.

Study
reference
Disease
(number of patients)
Autograft immune effector cells2-year overall survival rates2-year progression-free survival rates

Dean et al., 2005 [24]Diffuse large B-cell lymphoma
(53)
DC 1 ≥ 0.06
0.45 × 109 cells/kg
55%
DC 1 < 0.06
0.45 × 109 cells/kg
35%
()

Schmidmaier et al., 2008 [25]Multiple myeloma
(41)
CD4 ≥ 0.45 × 109
cells/kg
80%
CD4 < 0.45 × 109
cells/kg
40%
()

Porrata et al., 2014 [26]Diffuse large B-cell lymphoma
(379)
Lymphocyte to monocyte ratio ≥ 1.085%75%
Lymphocyte to monocyte ratio < 1.040%30%
()()

Porrata et al., 2014 [27]Hodgkin’s lymphoma
(183)
Lymphocyte to monocyte ratio ≥ 1.095%85%
Lymphocyte to monocyte ratio < 1.060%30%
()()

Porrata et al., 2015 [28]T-cell non-Hodgkin’s lymphoma
(109)
Lymphocyte to monocyte ratio ≥ 1.090%80%
Lymphocyte to monocyte ratio < 1.045%30%
()()

Porrata et al., 2016 [29]Non-Hodgkin’s lymphoma
(122)
NK ≥ 0.06
0.45 × 109 cells/kg
85%79%
NK < 0.06
0.45 × 109 cells/kg
70%45%
()()

DC: dendritic cells; NK: natural killer cells.