Advances in Hematology / 2016 / Article / Tab 2

Review Article

Choice of Unmanipulated T Cell Replete Graft for Haploidentical Stem Cell Transplant and Posttransplant Cyclophosphamide in Hematologic Malignancies in Adults: Peripheral Blood or Bone Marrow—Review of Published Literature

Table 2

Patients, donors, and graft characteristics.

ReferencePts. numberMed. age (range)DonorsDiseaseMed. CD34 ×106Med. CD3 ×108

O’Donnell et al., 2002 [24]1353Parent 16%
Sib 38%
Child 46%
AML/MDS 7
ALL 2
CML 2
MM 1
NHL 1
5.30.32

Luznik et al., 2008 [25]6846Parent 28%
Sib 48%
Child 24%
AML/MDS 28
ALL 4
CML/CMML 6
CLL/NHL 13
HL 13
MM 3
PNH 1
4.80.42

Symons et al., 2011 [26]3043NAAML 16
3 ALL
2 CML
9 NHL
NANA

Brunstein et al., 2011 [27]5048Parent 30%
Sib 34%
Child 36%
AML 22
ALL 9
NHL 12
HL 7
NANA

Pingali et al., 2014 [28]8446Parent 15%
Sib 42%
Child 42%
Cousin 1%
AML/MDS 49
ALL 10
CML 9
Lymphoma 13
3 others
NANA

Solomon et al., 2012 [29]2044Parent 15%
Sib 65%
Child 20%
AML 20
ALL 2
NHL 2
HL 1
CML 3
51.73

Raiola et al., 2013 [30]5042NAAML 25
ALL 12
Lymphoma 5
MPD 5
CML 3
40.35

Raj et al., 2014 [31]5549Parent 24%
Sib 37%
Child 39%
AML/MDS 21
ALL 2
NHL 12
HL 9
6.42

Bhamidipati et al., 2014 [32]1841Parent 28%
Sib 33%
Child 39%
AML 12
ALL 2
NHL 2
Other 2
51.97

Castagna et al., 2014 [33]BM, (67%)44NAAML/MDS 2
ALL 2
HL 23
NHL/CLL 16
MM 2
30.34
PBSC, (33%)54NAAML/MDS 2
HL 6
NHL/CLL 12
MM 2
5.12.73

Solomon et al., 2015 [34]3046.5Parent 7%
Sib 40%
Child 53%
AML/MDS 17
ALL 6
CML 5
NHL 2
5.011.55

Bradstock et al., 2015 [35]BM, 53Parent 7%
Sib 66%
Child 27%
AML 10
NHL 2
CML 1
2.5NA
PBSC, 44AML/MDS 11
NHL 4
ALL 4
Other 4
5.8NA

Gayoso et al., 2013 [36]8037Parent 35%
Sib 44%
Child 21%
AML/MDS 30
NHL 5
HL 29
ALL 9
Other 6
NANA

Sugita et al., 2015 [37]3148Parent 22.6%
Sib 29%
Child 45.1%
Other 3.2%
AML/MDS 21
ALL 8
NHL 2
4.0NA

ALL, acute lymphoid leukemia/lymphoma; AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; HL, Hodgkin lymphoma; MDS, myelodysplastic syndrome; MM, multiple myeloma; MPD, myeloproliferative disorder; NHL, non-Hodgkin lymphoma; PNH, paroxysmal nocturnal hemoglobinuria.

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