Choice of Unmanipulated T Cell Replete Graft for Haploidentical Stem Cell Transplant and Posttransplant Cyclophosphamide in Hematologic Malignancies in Adults: Peripheral Blood or Bone Marrow—Review of Published Literature

Table 2

Patients, donors, and graft characteristics.


Reference	Pts. number	Med. age (range)	Donors	Disease	Med. CD34 ×10⁶	Med. CD3 ×10⁸

O’Donnell et al., 2002 [24]	13	53	Parent 16% Sib 38% Child 46%	AML/MDS 7 ALL 2 CML 2 MM 1 NHL 1	5.3	0.32

Luznik et al., 2008 [25]	68	46	Parent 28% Sib 48% Child 24%	AML/MDS 28 ALL 4 CML/CMML 6 CLL/NHL 13 HL 13 MM 3 PNH 1	4.8	0.42

Symons et al., 2011 [26]	30	43	NA	AML 16 3 ALL 2 CML 9 NHL	NA	NA

Brunstein et al., 2011 [27]	50	48	Parent 30% Sib 34% Child 36%	AML 22 ALL 9 NHL 12 HL 7	NA	NA

Pingali et al., 2014 [28]	84	46	Parent 15% Sib 42% Child 42% Cousin 1%	AML/MDS 49 ALL 10 CML 9 Lymphoma 13 3 others	NA	NA

Solomon et al., 2012 [29]	20	44	Parent 15% Sib 65% Child 20%	AML 20 ALL 2 NHL 2 HL 1 CML 3	5	1.73

Raiola et al., 2013 [30]	50	42	NA	AML 25 ALL 12 Lymphoma 5 MPD 5 CML 3	4	0.35

Raj et al., 2014 [31]	55	49	Parent 24% Sib 37% Child 39%	AML/MDS 21 ALL 2 NHL 12 HL 9	6.4	2

Bhamidipati et al., 2014 [32]	18	41	Parent 28% Sib 33% Child 39%	AML 12 ALL 2 NHL 2 Other 2	5	1.97

Castagna et al., 2014 [33]	BM, (67%)	44	NA	AML/MDS 2 ALL 2 HL 23 NHL/CLL 16 MM 2	3	0.34
Castagna et al., 2014 [33]	PBSC, (33%)	54	NA	AML/MDS 2 HL 6 NHL/CLL 12 MM 2	5.1	2.73

Solomon et al., 2015 [34]	30	46.5	Parent 7% Sib 40% Child 53%	AML/MDS 17 ALL 6 CML 5 NHL 2	5.01	1.55

Bradstock et al., 2015 [35]	BM,	53	Parent 7% Sib 66% Child 27%	AML 10 NHL 2 CML 1	2.5	NA
Bradstock et al., 2015 [35]	PBSC,	44	Parent 7% Sib 66% Child 27%	AML/MDS 11 NHL 4 ALL 4 Other 4	5.8	NA

Gayoso et al., 2013 [36]	80	37	Parent 35% Sib 44% Child 21%	AML/MDS 30 NHL 5 HL 29 ALL 9 Other 6	NA	NA

Sugita et al., 2015 [37]	31	48	Parent 22.6% Sib 29% Child 45.1% Other 3.2%	AML/MDS 21 ALL 8 NHL 2	4.0	NA

ALL, acute lymphoid leukemia/lymphoma; AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; HL, Hodgkin lymphoma; MDS, myelodysplastic syndrome; MM, multiple myeloma; MPD, myeloproliferative disorder; NHL, non-Hodgkin lymphoma; PNH, paroxysmal nocturnal hemoglobinuria.

Advances in Hematology

Choice of Unmanipulated T Cell Replete Graft for Haploidentical Stem Cell Transplant and Posttransplant Cyclophosphamide in Hematologic Malignancies in Adults: Peripheral Blood or Bone Marrow—Review of Published Literature

Table 2