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Advances in Hematology
Volume 2017, Article ID 7878605, 7 pages
Research Article

Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis

1Department of Pediatrics, University Hospital of Ioannina, Ioannina, Greece
2Department of Internal Medicine, University Hospital of Ioannina, Ioannina, Greece
3Hematology Laboratory, University Hospital of Ioannina, Ioannina, Greece
4Hematology Department, University Hospital of Ioannina, Ioannina, Greece

Correspondence should be addressed to Alexandros Makis;

Received 25 October 2017; Accepted 15 November 2017; Published 6 December 2017

Academic Editor: Michelle Baccarani

Copyright © 2017 Alexandros Makis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immune thrombocytopenia (ITP) in children has a varied course and according to duration is distinguished as newly diagnosed (<3 months), persistent (3–12), and chronic (>12) types. Several studies have evaluated the prognostic factors for the progression of the disease, but similar works have yet to be performed in Greece. We aimed to identify prognostic markers for the three forms of the disease in 57 Greek children during a 13-year period. Information regarding age, gender, preceding infection, bleeding type, duration of symptoms and platelets at diagnosis, treatment, disease course, and immunological markers was recorded. 39 children had newly diagnosed, 4 persistent, and 14 chronic disease. Chronic ITP children were more likely to be of age > 10 years and have gradual initiation of the disease , platelets > 10 × 109/L , and impaired immunological markers compared to newly diagnosed/persistent groups. Recent history of infection was found mainly in the newly diagnosed/persistent group . None of the children exhibited severe spontaneous bleeding. Conclusion. Even though ITP in children usually has a self-limited course, with rare serious bleeding complications, the chronic form of the disease is characterized by different predictive parameters, which can be used in clinical practice.