Review Article
The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes
Table 1
Common gene mutations in MDS and the prognostic values [
3].
| Genes | Prognostic Impact |
| Epigenetic Regulators | | TET2 | poor | EZH2 | poor | ASXL1 | poor | DNMT3A | poor | IDH1/IDH2 | poor | Spliceosomal genes | | SF3B1 | good | U2AF1 | poor | SRSF2 | poor | ZRSR2 | unknown | Cytoplasmic tyrosine kinases | | JAK2 | poor | Signaling molecules | | SETBP1 | poor | NRAS | poor | Transcriptional factors | | ETV6 | poor | RUNX1 | poor | Tumor suppressors | | TP53 | poor | ROBO1/ROBO2 | poor | Chromatid cohesion | | STAG2 | poor |
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