Review Article

The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes

Table 1

Common gene mutations in MDS and the prognostic values [3].

GenesPrognostic Impact

Epigenetic Regulators
TET2poor
EZH2poor
ASXL1poor
DNMT3Apoor
IDH1/IDH2poor
Spliceosomal genes
SF3B1good
U2AF1poor
SRSF2poor
ZRSR2unknown
Cytoplasmic tyrosine kinases
JAK2poor
Signaling molecules
SETBP1poor
NRASpoor
Transcriptional factors
ETV6poor
RUNX1poor
Tumor suppressors
TP53poor
ROBO1/ROBO2poor
Chromatid cohesion
STAG2poor