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Advances in Hematology
Volume 2018, Article ID 3864398, 6 pages
Research Article

Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma

Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Central Jakarta 10430, Indonesia

Correspondence should be addressed to Adi Surya Komala;

Received 11 October 2017; Revised 25 January 2018; Accepted 5 February 2018; Published 5 March 2018

Academic Editor: Bashir A. Lwaleed

Copyright © 2018 Adi Surya Komala and Andhika Rachman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Methods. Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC). Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit. Results. The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, ; 841/μL versus 528/μL, ). Plasma levels of sP-selectin in group IVC were higher than group I-IVA (59.5 ng/mL versus 41.97 ng/mL, ) and group IVB (59.5 ng/mL versus 45.53 ng/mL, ). In subjects with high monocyte count (>665/μL), there was moderate correlation between monocyte count and sP-selectin (, ). Conclusion. Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup.