Assessing the Performance of Extended Half-Life Coagulation Factor VIII, FC Fusion Protein by Using Chromogenic and One-Stage Assays in Saudi Hemophilia A Patients
Table 1
The comparison between the one-stage assay versus chromogenic assay for the measurement of factor VIII levels in the study population.
Time of sample collection
N
One-stage assay†
Chromogenic assay†
Mean difference
SE
value
95% CI
>1 day
11
0.22 (0.23)
0.33 (0.31)
−0.10
0.03
0.014
−0.18 to −0.27
>2 days
10
0.08 (0.07)
0.13 (0.10)
−0.05
0.018
0.026
−0.09 to −0.007
>3 days
10
0.02 (0.03)
0.09 (0.077)
−0.06
0.02
0.024
−0.11 to −0.01
>4 days
11
0.02 (0.02)
0.07 (0.06)
−0.05
0.018
0.022
−0.09 to −0.008
>5 days
8
0.01 (0.004)
0.07 (0.08)
−0.06
0.03
0.077
−0.13 to −0.008
Others
6
0.1 (0.11)
0.13 (0.16)
−0.03
0.019
0.105
−0.08 to 0.011
All samples
56
0.08 (0.13)
0.14 (0.18)
−0.06
0.08
˂0.001
−0.08 to −0.04
N = number of samples evaluated; † data reported in mean (standard deviation); SE = standard error; CI = confidence interval; others: includes samples collected after more than one week.
