Review Article

Ribavirin at the Era of Novel Direct Antiviral Agents for the Treatment of Hepatitis C Virus Infection: Relevance of Pharmacological Monitoring

Table 3

Virological response for dialysis patients or for patients with renal insufficiency (perprotocol analysis).

Patients
()
Dialysis patients
() (%)
Patients with moderate or severe renal insufficiency
() (%)

Virological response at W12
 EVR13/1723/46
 RVR2/171/46
 cEVR710
 pEVR412

Virological response at W248/13 (62)14/40 (35)
HCV genotype
 14/8 (50)8/31 (26)
 22/2 (100)3/3 (100)
 31/1 (100)3/5 (60)
 41/2 (50)0/1 (0)
Fibrosis stage
 F0/F1/F26/8 (75)11/29 (38)
 F3/F42/5 (40)6/11 (55)

Early treatment discontinuation25
 Severe anaemia14
 Death10
 Intolerance to interferon 01

cEVR, complete early virological response; EVR, early virological response; pEVR, partial early virological response; RVR, rapid virological response.