Hepatitis B Virus Infection and the Kidney: Renal Abnormalities in HBV Patients, Antiviral Drugs Handling, and Specific Follow-Up

Table 5

Drug dosing recommendations for entecavir in CHB patients with CKD.

eGFR (mL/Min)	Dosage recommended
	Usual dose	Lamivudine-resistant patients
≥90	0.5 mg/day	1 mg/day
<90–50	0.5 mg/day	1 mg/day
<50–30	0.5 mg every 48 hours	0.5 mg/day
<30–10	0.5 mg every 72 hours	0.5 mg every 48 hours
<10	0.5 mg once a week	0.5 mg every 72 hours
HD^*	0.5 mg once a week	0.5 mg every 72 hours
CAPD	0.5 mg once a week	0.5 mg every 72 hours

 ^*In hemodialysis patients, entecavir should be administered on a hemodialysis day, after the session.
eGFR: estimated glomerular filtration rate.
Source: http://www.sitegpr.com/.