Abstract

A brief review is given of the current state of the problem of neutrino pair emission through neutral weak currents caused by the Cooper pairs breaking and formation (PBF) in superfluid baryon matter at thermal equilibrium. The cases of singlet-state pairing with isotropic superfluid gap and spin-triplet pairing with an anisotropic gap are analyzed with allowance for the anomalous weak interactions caused by superfluidity. It is shown that taking into account the anomalous weak interactions in both the vector and axial channels is very important for a correct description of neutrino energy losses through the PBF processes. The anomalous contributions lead to an almost complete suppression of the PBF neutrino emission in spin-singlet superfluids and strong reduction of the PBF neutrino losses in the spin-triplet superfluid neutron matter, which considerably slows down the cooling rate of neutron stars with superfluid cores.

1. Introduction

At the long cooling era, the evolution of a neutron star (NS) surface temperature crucially depends on the overall rate of neutrino emission out of the star. The cooling dynamics below the superfluid transition temperature is governed primarily by the superfluid component of nucleon matter. The superfluidity of nucleons in NSs strongly suppresses most mechanisms of neutrino emission operating in the nonsuperfluid nucleon matter (the bremsstrahlung at nucleon collisions, modified Urca processes, etc. [1, 2]) but simultaneously strongly reduces the heat capacity and triggers the emission of neutrino pairs through neutral weak currents caused by the nucleon Cooper pair breaking and formation (PBF) processes in thermal equilibrium. Neutrino emission from Cooper pairs is currently thought to be the dominant cooling mechanism of baryon matter, for some ranges of the temperature and/or matter density. The total energy and momentum of an escaping (massless) neutrino pair form a time-like four-momentum , so the process is kinematically allowed only because of the existence of a superfluid energy gap , which admits the nucleon transitions with and . (We use the Standard Model of weak interactions, the system of units , and the Boltzmann constant .)

The simplest case for baryon pairing corresponds to two particles correlated in the state with the total spin and orbital momentum . The neutrino emissivity due to the PBF processes in the spin-singlet superfluid nucleon matter was first suggested and calculated by Flowers et al. [3]. The result of this calculation was recovered later by other authors [46]. Similar mechanism for the neutrino energy losses due to spin-singlet pairing of hyperons was suggested in [79]. For more than three decades these ideas were a key ingredient in numerical simulations of NS evolution (e.g., [1012]). However, after such a long period, it was unexpectedly found that the PBF emission of neutrino pairs is practically absent in a nonrelativistic spin-singlet superfluid liquid [13]. Later this result was confirmed in other calculations [1416]. (Note also the controversial work [17].)

The importance of the suppression of the PBF neutrino emission from the superfluid was first understood in [18] in connection with the fact that the previous theory predicted a too rapid cooling of the NS’s crust, which dramatically contradicts the observed data of superbursts [19].

The neutron pairing in NS is essentially restricted to the crust. As a result, in the NS evolution, effects of the suppression are mostly observed during the thermal relaxation of the crust [2022]. The significant revision of PBF neutrino emission from this relatively thin layer does not change substantially the total energy losses from the star. The most neutrino losses occur from the NS core, which occupies more than 90% of the star’s volume and contains the superfluid neutrons paired in the state with , , and [23, 24].

In the commonly used version of the minimal cooling paradigm, the emission of pairing was reduced by only about 30% due to the suppression of the vector channel of weak interactions [22, 25, 26]. This approach does not take into account the anomalous axial-vector weak interactions, existing due to spin fluctuations in the spin-triplet superfluid neutron matter [27]. Some simulations of the NS evolution accounting for the anomalous contributions predict a raising of its surface temperature and argue that a full exploration of this effect is necessary [28] (also see [29, 30]).

A correct description of the efficiency of neutrino emission in the PBF processes allows for a better understanding of observations [3133]. This review is devoted to the current state of this problem. Since the complete calculations have been published repeatedly (e.g., [13, 27, 34]), I will briefly sketch the main steps of the derivation, referring the reader to the original papers for more detailed information.

2. Preliminary Notes

The low-energy Hamiltonian of the weak interaction may be described in a point-like approximation. For interactions mediated by neutral weak currents, it can be written as follows (e.g., [1]): Here is the Fermi coupling constant, and the neutrino weak current is given by , where are Dirac matrices () and . The neutral weak current of the baryon, , represents the combination of the vector and axial-vector terms, and , respectively. Here represents the baryon field. The weak coupling constants and are determined by quark composition of the baryons. For the reactions with neutrons, one has and , while, for those with protons, and , where is the axial-vector constant. Notice that similar interaction Hamiltonian, but with other coupling constants, describes the neutrino weak interaction of hyperons in NS matter (e.g., [35]).

In the nonrelativistic nucleon system, the vector part of the weak current can be approximated by its temporal componentwhere . Throughout the text, a hat means a matrix in spin space and . The axial weak current is given dominantly by its space component where are Pauli spin matrices.

It is important to notice that the vector weak current is conserved in the standard theory. The conservation law implies that the transition matrix element in the vector channel of the reaction obeys the relationThe transferred momentum enters into the medium response function through the quasiparticle energy, which for in a degenerate Fermi liquid takes the form . Thus, in the absence of external fields, the momentum transfer enters the response function of the medium only in combination with the Fermi velocity, which is small in the nonrelativistic system, . Therefore, for the PBF processes the relation is always satisfied. This allows one to evaluate the medium response function in the long-wave limit . Together with the conservation law (4) this immediately yields for , which means that the neutrino pair emission through the vector channel of weak interactions is strongly suppressed in the nonrelativistic system. This important fact was overlooked for a long time, since a direct calculation shows that the matrix element for the recombination of two Bogolons into the condensate does not vanish, which erroneously leads to a large neutrino emissivity through the vector channel.

First calculations of the PBF neutrino energy losses were performed using a vacuum-type weak interactions assuming that the medium effects can be taken into account by introducing effective masses of participating quasiparticles [3, 6]. This resulted in a substantial overestimate of the PBF neutrino energy losses from the superfluid core and inner crust of NSs. Only three decades later has it been understood that the calculation of neutrino radiation from a superfluid Fermi liquid requires a more delicate approach.

Within the Nambu-Gor’kov formalism the effective vertex of nucleon interactions with an external neutrino field represents a matrix in the particle-hole space. This matrix is diagonal for nucleons in the normal Fermi liquid but it gets the off-diagonal entries in superfluid systems [3639]. The diagonal elements represent the ordinary (dressed) vertices of the field interaction with quasiparticles and holes, respectively, while the off-diagonal elements of the matrix represent the effective vertices for a virtual breaking and formation of Cooper pairs in the external field. In other words, the off-diagonal components of the vertex matrix describe a coupling of the external field with fluctuations of the order parameter in the superfluid Fermi liquid. These so-called “anomalous weak interactions” should be necessarily taken into account when calculating the neutrino energy losses from superfluid cores of NSs.

In particular, the anomalous weak interactions are crucial for the neutrino emission caused by the PBF processes. For example, in nonrelativistic systems, the ordinary and anomalous contributions into the matrix element of the weak vector transition current are mutually cancelled in the long-wave limit, leading to a strong suppression of the PBF neutrino emission [13]. The more accurate calculation [14, 16] has shown that the neutrino pair emission owing to the density fluctuations is suppressed proportionally to . This reflects the well known fact that the dipole radiation is not possible in the vector channel in the collision of two identical particles. Thus, exactly due to the anomalous contributions, the PBF neutrino emission in the vector channel of weak interactions is practically absent.

In the case of pairing this has far-reaching consequences. The total spin of the nonrelativistic Cooper pair is conserved. Therefore the neutrino emission through the axial-vector channel of weak interactions could arise only due to small relativistic effects and is proportional to [3, 15]. Thus the PBF neutrino energy losses due to singlet-state pairing of baryons can, in practice, be neglected in simulations of NS cooling. This makes the neutrino radiation from pairing of protons or hyperons unimportant.

The minimal cooling paradigm [22] suggests that, below the critical temperature for a triplet pairing of neutrons, the dominant neutrino energy losses occur from the superfluid neutron liquid in the inner core of a NS. It is commonly believed [23, 24, 4042] that, in this case, the pairing (with a small admixture of state) takes place with a preferred magnetic quantum number . Since the spin of a Cooper pair in the state is the spin fluctuations are possible and the PBF neutrino energy losses from the neutron superfluid occur through the axial channel of weak interactions.

The pairing interaction, in the most attractive channel, can be written as [23] where is the corresponding interaction amplitude; and are the Fermi momentum and the neutron effective mass, respectively, so that is the density of states near the Fermi surface. The angular dependence of the interaction is represented by Cartesian components of the unit vector which involves the polar angles on the Fermi surface, Further, is a real vector in the spin space, normalizable by conditionHereafter we use the angle brackets to denote angle averages,

For spin-triplet pairing, the order parameter is a symmetric matrix in the spin space, which near the Fermi surface can be written as follows (see, e.g., [43]): where the temperature-dependent gap amplitude is a real constant.

The vector defines the angle anisotropy of energy gap which depends on the phase state of the superfluid condensate. In general, this vector can be written in the form , where is a matrix. In the case of a unitary condensate the matrix must be a real symmetric traceless tensor. It may be specified by giving the orientation of its principal axes and its two independent diagonal elements in its principal-axis coordinate system. Within the preferred coordinate system, the ground state with is described by the matrix and .

3. General Approach to Neutrino Energy Losses

Thermal fluctuations of the neutral weak currents in nucleon matter are closely related to the imaginary, dissipative part of the response function of the medium onto the external neutrino field. According to the fluctuation-dissipation theorem, the total energy loss per unit volume and time caused by thermal fluctuations of the neutral weak current in the nucleon matter is given by the following formula: where is the imaginary part of the retarded weak polarization tensor. The integration goes over the phase volume of neutrinos and antineutrinos of total energy and total momentum . The symbol indicates a summation over three neutrino flavors. The factor occurs as a result of averaging over the Gibbs distribution, which must be performed at finite ambient temperatures.

By inserting in this equation and making use of the Lenard’s integral where , , is the Heaviside step function, and is the signature tensor, we can write where is the number of neutrino flavors.

In general, the weak polarization tensor of the medium is a sum of the vector-vector, axial-axial, and mixed terms. The mixed vector-axial polarization has to be an antisymmetric tensor, and its contraction in (13) with the symmetric tensor vanishes. Thus only the pure-vector and pure-axial polarization should be taken into account. We then obtain where and are vector and axial-vector weak coupling constants of a neutron, respectively.

4. Weak Interactions in Superfluid Fermi Liquids

Physically, the polarization tensor represents a correction to the Z-boson self-energy in the medium. Making use of the adopted graphical notation for the ordinary and anomalous propagators, = , = , = , and = , one can represent the polarization function in each of the channels as the sum of graphs depicted in Figure 1.

As can be seen, the field interaction with superfluid fermions should be described with the aid of four effective three-point vertices. There are two usual effective vertices (shown by dots) corresponding to the creation of a particle and a hole by the Z-field. Let us denote them as and , respectively. We omit the Dirac indices in these symbolic notations. In reality, according to (2) and (3), the nonrelativistic ordinary vector vertex is represented by its temporal component; that is, it is a scalar matrix in spin space. The ordinary axial-vector vertices of a particle and a hole are represented by space-vectors whose components consist of spin matrices.

Two more vertices, represented by triangles, correspond to the creation of two particles or two holes. These so-called “anomalous” vertices appear because the pairing interaction among quasiparticles is to be incorporated in the coupling vertex up to the same degree of approximation as in the self-energy of a quasiparticle [36, 37]. This means that the anomalous effective vertices are given by infinite sums of diagrams with allowance for pair interaction in the ladder approximation, in the same way as in the gap equations.

Given by the sum of ladder-type diagrams [38], the anomalous vertices are to satisfy Dyson’s equations symbolically depicted by graphs in Figure 2(a). In these graphs, the rectangles denote pairing interaction, which in the channel of two quasiparticles is given by (5). The vertex equations are to be supplemented by the gap equation shown graphically in Figure 2(b). This equation, whose solution is assumed to be known, serves to eliminate the amplitude of the pair interaction from the vertex equations near the Fermi surface. The standard gap equation involves integrations over the regions far from the Fermi surface. This integration can be eliminated by means of the renormalization of the pairing interaction, as suggested in [39]. Details of this calculation can be found in [34].

The analytic form of the quasiparticle propagators in the momentum representation can be written as Making use of the Matsubara calculation technique we define the scalar part of the Green functionsHere with being the fermionic Matsubara frequency which depends on the temperature , andstands for the Bogolon energy. The angle-dependent energy gap is given by .

It should be noted that, by virtue of (7), the amplitude is chosen to represent the energy gap averaged over the Fermi surface. Thus determined, the energy gap gives a general measure of the pairing correction to the energy of the ground state in the preferred state.

In general, the ordinary vertices in the Dyson equations should be dressed owing to residual Fermi-liquid interactions. We neglect this effect and account for the residual interactions by means of the effective nucleon mass only. In this case the ordinary vertices are as defined in (2) and (3). Namely, the nonrelativistic ordinary vector vertex is represented by its temporal component The ordinary axial-vector vertices of a particle and a hole are to be taken as where the superscript “” transposes the matrix.

In the case of pairing in the channel with spin, orbital, and total angular momenta, , respectively, one can search for the anomalous vertices near the Fermi surface in the form of expansions over the eigenfunctions of the total angular momentum with and . For our calculations it is convenient to use vector notation which involves a set of mutually orthogonal complex vectors in spin space which generates standard spin-angle matrices according to where denote spin projections.

These vectors are of the form These are normalized by the condition

Generally speaking, the anomalous vertices are functions of the transferred energy and momentum and the direction of the quasiparticle momentum. As was mentioned in Introduction, it is sufficient to evaluate the medium response function in the limit . Then the nonrelativistic anomalous vector vertex can be expanded in the eigenfunctions of the total angular momentum in the form Accordingly, the anomalous axial-vector vertices can be represented in the form

Making use of these general forms in the Dyson equations together with the corresponding ordinary vertices, after tedious computations, one can get [34] in the vector channelwhere obeys the equation In the axial-vector channel one findswith satisfying the equation In the above expressions, the following notation is used:The functions and are given by

From (26) and (28) it is seen that an accurate calculation of the anisotropic anomalous vertices at arbitrary temperatures apparently requires numerical computations. It would be desirable, however, to get reasonable analytic expressions for the anomalous vertices, which can be applied to a calculation of the neutrino energy losses. To proceed, let us notice that the anisotropy of the functions and is due to the dependence of the energy of the Bogolons (17) on the direction of the momentum relative to the quantization axis. In a uniform system without external fields and at absolute zero, the orientation of the quantization axis is arbitrary. For equilibrium at a nonzero temperature this leads to the formation of a loose domain structure [44], where each microscopic domain has a randomly oriented preferred axis. This fact is normally used in order to simplify the calculations by replacing the angle-dependent energy gap with some effective isotropic value (see, e.g., [45, 46]).

Making use of this trick we replace the angle-dependent energy gap in the Bogolons energy by its average value , in accordance with (7). Then the functions and can be moved out of the integrals over the solid angle in (26) and (28). Using further the axial symmetry of the order parameter, (22), and the fact that we get for the vector channel the equation In the axial channel we obtain the equation The specific form of solutions to (33) and (34) depends on the phase state of the condensate.

An inspection of (10) and (21) allows one to conclude that for the ground state with ,In this case we get , and the only nonvanishing values of correspond to . Simple calculations givewhere

Substituting the obtained expressions to (23)–(24) we get the anomalous vertices which, together with the ordinary vertices (18) and (19), can be used to calculate the weak polarization tensor of the medium. We now turn to a calculation of the corresponding correlation functions separately in the vector and axial channel of weak interactions.

5. Correlation Functions of Weak Currents

5.1. Vector Channel

Following the graphs of Figure 1 the vector-vector part of the polarization tensor, , is given by analytic continuation of the following Matsubara sums to the upper half-plane of the complex variable :We use the notations and , where with being a bosonic Matsubara frequency.

The two first terms in the right-hand side of (39) describe the medium polarization without anomalous contributions. The long-wave limit of this ordinary contribution in the vector channel can be found in the form Evidently this expression does not satisfy the condition of current conservation , which in the long-wave limit requires .

The last two terms in (39), with the vertices indicated in (23), represent the anomalous contributions. According to (25) and (36) the anomalous vector vertices can be written as Straightforward calculations give in the long-wave limitWe finally findas is required by the current conservation condition. This proves explicitly that the neutrino emissivity via the vector channel, as initially obtained in [6], is a subject of inconsistency.

5.2. Axial Channel

In the axial channel, the ordinary vertices (19) and anomalous vertices (46) consist of only space components, and thus , where is to be found as the analytic continuation of the following Matsubara sums:Here the first line represents the ordinary contribution and the second line is the contribution of the anomalous interactions. The ordinary contribution can be evaluated in the formIn the case of , when , from (24), (37), and (38), we get Poles of the vertex function correspond to collective eigenmodes of the system (see, e.g., [34, 47, 48]). Thus, the pole at signals the existence of collective oscillations of the total angular momentum. The pole location on the complex -plain is chosen so as to obtain a retarded vertex.

Principally, the decay of these collective oscillations into neutrino pairs is also possible by giving the additive contribution into neutrino energy losses via the axial channel of weak interactions. Later we will return to this problem. Here we concentrate on the PBF processes. In this case we are interested in , and a small term in the denominator of (46) can be discarded to obtain simpler expressions

Substituting expressions (47) in the second line of (44) we obtain the anomalous part of the axial polarization tensor in the long-wave limit:

Summing together the contributions, given in (45) and (48), we obtain the complete response function in the axial channel: The imaginary part of the function arises from the poles of the integrand in (30) at :

Using (50) and (14), (43), and (49) we obtain the imaginary part of the weak polarization tensor for the superfluid neutron liquid:

6. PBF Neutrino Energy Losses

Now we substitute the obtained weak polarization tensor to (13) for the neutrino emissivity. Contraction of the tensor (51) with gives where we denote After some algebra we find the neutrino emissivity in the following form:where and .

It is necessary to notice that a definition of the gap amplitude is ambiguous in the literature. For example, in the case of , our gap amplitude is times larger than the gap amplitude in [6] (denote it by ), where it is defined by the relation . However, the total anisotropic gap entering the energy of the quasiparticles is the same in both calculations, since .

Returning to the standard physical units we get the following [27]: Remember that is the Fermi coupling constant, is the axial-vector weak coupling constant of a neutron, and is the number of neutrino flavors; is the Fermi momentum of neutrons, is the effective neutron mass; is bare nucleon mass, , is the Boltzmann constant, andThe function is given byHere the notation used is with . The unit vector defines the polar angles on the Fermi surface.

It is necessary to stress that (54) as well as (55) involves the anomalous contributions into both the channels of weak interactions (vector and axial). A comparison of the formula (56) with (26) of the work [6], where the PBF neutrino losses were obtained ignoring the anomalous interactions, allows one to see that the anomalous contributions not only completely suppress the vector channel of weak interactions, but also suppress four times the energy losses through the axial channel. The resulting reduction of the emissivity of the PBF processes in neutron matter is as follows [27]:

In spite of the so strong reduction, the neutrino emissivity caused by the PBF processes can be the most powerful mechanism of the energy losses from the NS core below the critical temperature . In Figure 3, the PBF neutrino emissivity, as given in (54), is shown together with the emissivities of modified Urca processes and bremsstrahlung multiplied by the corresponding suppression factors resulting from superfluidity, as obtained in [49].

The emissivity from the PBF dominates everywhere below the critical temperature for the superfluidity except the narrow temperature domain near the critical point, where the modified Urca processes are more operative.

7. Decay of the Eigenmodes of the Condensate

We now turn to an estimate of the neutrino energy losses due to decay of thermally excited oscillations of the spin-triplet condensate of neutrons. These eigenmodes represent collective oscillations of the direction of total angular momenta of Cooper pairs which generate fluctuations of axial currents in the superfluid system (spin density fluctuations). The energy of the collective mode excitation is smaller than the energy gap in the quasiparticle spectrum. In this case the function , given in (30), is real, and the imaginary part of the axial polarization tensor (44) arises from the pole part of the functions at .

With the aid of Sokhotsky’s formula, , from the second line of (44) we get The neutrino luminosity per unit volume is proportional to the product of the total phase volume available to the outgoing neutrinos and the total energy of the neutrino pair. This explains the temperature dependence of the PBF neutrino emissivity, as given in (54). The presence of the delta-function in (59) restricts the total energy of the neutrino pair by the dispersion relation and thus substantially reduces the total volume available to neutrino pairs in the phase space. Integration over the phase volume will result in appearance of the factor instead of . Just below the superfluid transition temperature, where the main splash of the PBF neutrino emission occurs, the collective mode energy is small as compared to the temperature. As a result the emissivity due to the collective mode decays is many orders of magnitude slower than the PBF emissivity.

One might expect the two emissivities to become comparable at sufficiently low temperature . It is necessary to notice, however, that our estimate is valid only when the anisotropic energy gap is replaced by its average value in the anomalous vertices. Such an approximation is good for the PBF processes but not for the eigen modes. The exact account of the anisotropy dramatically reduces the neutrino losses due to the collective mode decays [50].

8. Application to Cooling Modeling of Neutron Stars

The strong suppression of the vector PBF channel is basically incorporated in the cooling simulations codes (e.g., [18, 22, 2830]). In the case of pairing of neutrons the suppression of the vector channel should be important in the cooling interpretation of a NS crust as the cooling time-scale of the crust is sensitive to the rates of neutrino emission. Quenching of the neutrino emission, found in the case of pairing, leads to higher temperatures that can be reached in the crust of an accreting NS. This allows one to explain the observed data of superbursts triggering [18, 19, 51, 52], which was in dramatic discrepancy with the previous theory of the crust cooling. However, the suppression of the neutron PBF process does not lead to a distinguishable effect in the long-term cooling (>1000 years) of the star [22].

The neutron pairing in the NS core is expected to occur into the spin-triplet state (a small admixture caused by tensor forces is normally neglected). Just a few years ago, suppression of the PBF neutrino emission due to spin-triplet neutron pairing in the NS core was included in the neutron star cooling codes only by complete suppression of the vector channel, while the emission in the axial-vector channel remained unchanged [22, 31]. This corresponds to the reduction factor of with respect to the PBF emissivity previously obtained in [6], which led the authors to the conclusion that, within the minimal cooling paradigm, the closing of the vector channel of the PBF neutrino emission does not significantly affect the long-term cooling of NSs. The reason is that the long-term cooling is controlled by the axial channel of the PBF emissivities.

The suppression factor for PBF neutrino radiation given in (58) involves two physical phenomena: (i) total suppression of the vector channel and (ii) the fourfold suppression of the axial channel caused by the anomalous weak interactions. For the first time the suppression of the axial PBF channel was implemented in a simulation of the Cas A NS cooling in [32, 53]. It was found that the whole set of observations is quite consistent with the theoretical suppression factor of . This factor, presented in (58), is now commonly used for suppression of the PBF reactions in spin-triplet superfluid neutron matter of the NS cores (e.g., [29, 30, 54, 55]).

An exhaustive numerical analysis of the anomalous axial PBF contribution to the temporal evolution of the NS cooling is presented in [56]. The interested reader can get a clear idea about importance of this contribution from Figures 2 and 3 of that work, where the authors present the NS cooling curves for the cases with and without the anomalous contribution.

9. Conclusion

We have discussed the important role of anomalous weak interactions in mechanisms of neutrino emission taking place in fermionic superfluids typical for the NS cores. It is established that due to the anomalous contributions the PBF neutrino emissivity from the vector channel is almost completely suppressed and can be ignored. This result is in agreement with the conservation of vector current in weak interactions. In the case of spin-singlet pairing the neutrino emission through the axial-vector channel is also suppressed because the total spin of the Cooper pair is conserved in the nonrelativistic case. Thus the neutrino energy losses due to singlet-state pairing of baryons can, in practice, be ignored in simulations of NS cooling. This makes the PBF neutrino losses from pairing of protons or hyperons unimportant.

The minimal cooling paradigm assumes that the direct Urca processes and any exotic fast reactions are not operative in the NC core. In this scenario, neutrino emission at the long-term cooling epoch comes mainly from modified Urca processes, nn-bremsstrahlung, and from the “PBF” processes, which arise in the presence of spin-triplet superfluidity of neutrons [22]. We have shown that the anomalous weak interactions in the superfluid suppress the PBF neutrino emission, although not so sharply as in spin-singlet superfluid liquids. Namely, the vector channel of weak interactions is again strongly suppressed and can be ignored while the neutrino losses through the axial channel are suppressed only partially. Despite the approximately fivefold total suppression, the PBF mechanism of the neutrino energy losses is still operative. In many cases, especially for temperatures near the critical superfluidity temperature of neutrons, the PBF neutrino reactions can dominate and should be accurately taken into account.

Conflicts of Interest

The author declares that there are no conflicts of interest regarding the publication of this article.