Beta2-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction
Table 2
Genotype and allele frequencies of ADRB2 gene polymorphisms in patients and controls.
Variables
Patients ()
Controls ()
value
Crude OR (95% CI)
Adjusted& OR (95% CI)
Arg16Gly polymorphism
Genotype frequency
Arg16/Arg16
10 (14.7)
08 (10.7)
0.010
0.919
1.0
1.0
Arg16/Gly16
30 (44.1)
40 (53.3)
0.6 (0.2–1.7)
0.3 (0.07–2.0)
Gly16/Gly16
28 (41.2)
27 (36.0)
0.8 (0.2–2.4)
1.9 (0.3–9.9)
Allele frequency
Arg16 allele
50 (36.8)
56 (37.3)
0.009
0.920
1.0
0.2 (0.1–0.7)
Gly16 allele
86 (63.2)
94 (62.7)
1.0 (0.6–1.6)
0.8 (0.2–3.7)
Gln27Glu polymorphism
Genotype frequency
Gln27/Gln27
34 (50.0)
22 (29.3)
4.012
0.045*
1.0
1.0
Gln27/Glu27
23 (33.8)
38 (50.7)
0.3 (0.1–0.8)*
0.5 (0.1–1.5)
Glu27/Glu27
11 (16.2)
15 (20.0)
0.4 (0.1–1.2)
1.9 (0.4–8.2)
Allele frequency
Gln27 allele
91 (66.9)
82 (54.7)
4.459
0.034*
1.0
0.2 (0.06–1.1)
Glu27 allele
45 (33.1)
68 (45.3)
0.5 (0.3–0.9) *
0.5 (0.1–1.5)
Values are shown as number (%). Chi-square () for trend was used. OR (95% CI): odds ratio and confidence interval. &Adjusted for confounding factors. Adjusted OR for alleles was calculated as presence versus absence of this particular allele. *Statistically significant at .
