Beta2-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction
Table 5
Disease characteristics of patients according to ADRB2 genotypes ().
Characteristics
Arg16Gly genotypes
value
Gln27Glu genotypes
value
Arg16/Arg16
Arg16/Gly16
Gly16/Gly16
Gln27/Gln27
Gln27/Glu27
Glu27/Glu27
Total number
10 (14.7)
30 (44.1)
28 (41.2)
34 (50.0)
23 (33.8)
11 (16.2)
Risk factors for CVD
Age at diagnosis
52 ± 7.4
53 ± 8.1
55 ± 6.6
0.577
53 ± 7.7
55 ± 7.7
53 ± 5.3
0.367
Male gender, %
7 (15.5)
22 (48.9)
16 (35.6)
0.412
22 (44.0)
21 (42.0)
7 (14.0)
0.059
Smokers, %
4 (10.8)
20 (54.1)
13 (35.1)
0.185
18 (48.7)
15 (40.5)
4 (10.8)
0.278
FH of CVD, %
7 (20.0)
16 (45.7)
12 (34.3)
0.325
21 (60.0)
10 (28.6)
4 (11.4)
0.219
Hypertension, %
10 (20.8)
20 (41.7)
18 (37.5)
0.085
32 (66.7)
12 (25.0)
4 (8.30)
<0.001*
DM, %
2 (6.25)
10 (31.3)
20 (62.5)
0.003*
14 (43.7)
11 (34.4)
7 (21.9)
0.429
BMI, Kg/m2
32 ± 3.8
30 ± 4.0
29 ± 3.6
0.080
30 ± 3.3
29 ± 4.1
28 ± 2.9
0.195
Lipid profile
Hyperlipidemia, %
10 (16.1)
28 (45.2)
24 (38.7)
0.336
31 (50.0)
20 (32.3)
11 (17.7)
0.455
Total cholesterol, mg/dL
202 ± 33
208 ± 38
188 ± 43
0.085
199 ± 41
207 ± 40
181 ± 32
0.139
Total triglyceride, mg/dL
228 ± 45
200 ± 74
195 ± 54
0.121
199 ± 56
199 ± 81
218 ± 38
0.199
HDL-C, mg/dL
38 ± 5.2
39 ± 6.7
37 ± 8.7
0.374
38 ± 7.7
39 ± 8.0
36 ± 4.8
0.883
LDL-C, mg/dL
119 ± 30
1129 ± 37
111 ± 46
0.125
122 ± 43
128 ± 39
101 ± 35
0.099
VLDL-C, mg/dL
46 ± 8.9
40 ± 15
39 ± 11
0.121
40 ± 11
40 ± 16
44 ± 7.5
0.199
Cardiac enzymes
CK, ng/mL
1624 ± 1422
1499 ± 1654
1912 ± 2149
0.746
1821 ± 2088
1717 ± 1735
1215 ± 1078
0.791
CK-MB. ng/mL
362 ± 412
328 ± 336
294 ± 402
0.306
294 ± 320
450 ± 470
126 ± 107
0.089
LDH, IU/L
1666 ± 603
1368 ± 1161
1733 ± 1437
0.289
1775 ± 1517
1301 ± 882
1451 ± 625
0.506
Values are shown as mean ± standard deviation or number (percentage). CVD: cardiovascular disease; DM: diabetes mellitus; BMI: body mass index; HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; CK: total creatine kinase; CK-MB: creatine kinase isoenzyme MB fraction; LDH: lactate dehydrogenase. Two-sided chi-square and Kruskal-Wallis tests were used. *Statistically significant at < 0.05.
