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Advances in Medicine
Volume 2016 (2016), Article ID 3194010, 6 pages
Clinical Study

Efficacy of Synbiotics for Treatment of Bacillary Dysentery in Children: A Double-Blind, Randomized, Placebo-Controlled Study

Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran

Received 21 April 2016; Revised 29 August 2016; Accepted 9 October 2016

Academic Editor: Aliya Naheed

Copyright © 2016 Manijeh Kahbazi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bacillary dysentery is a major cause of children’s admission to hospitals. To assess the probiotic and prebiotic (synbiotics) effects in children with dysentery in a randomized clinical trial, 200 children with dysentery were studied in 2 groups: the synbiotic group received 1 tablet/day of synbiotic for 3–5 days and the placebo group received placebo tablets (identical tablet form like probiotics). The standard treatment was administered for all patients. Duration of hospitalization, dysentery, fever, and the weight loss were assessed in each group. It was concluded that there was no significant difference in both groups in the baseline characteristics. The mean duration of dysentery reduced (). The mean duration of fever has been significantly reduced in the synbiotic group ( days) in comparison to the placebo group ( days) (). Average amount of weight loss was significantly lower in the synbiotic group in comparison to that in the placebo group ( grams and grams, resp.; ). There was no significant difference in the mean duration of hospitalization in both groups (). The use of synbiotics as an adjuvant therapy to the standard treatment of dysentery significantly reduces the duration of dysentery, fever, and rate of weight losses. The trial is registered with IRCT201109267647N1.