Research Article
Basal Insulin Dose in Adults with Type 1 Diabetes Mellitus on Insulin Pumps in Real-Life Clinical Practice: A Single-Center Experience
Table 1
Study group characteristics and the comparison between T1DM patients with in-target HbA1c and above-target HbA1c are shown.
| | Variables | Whole group | HbA1c ≤7% | HbA1c >7% | | | Mean | SD | Median | Range | Mean | SD | Mean | SD |
| | Age (years) | 26.6 | 8.2 | 24.0 | 18–69 | 27.9 | 8.9 | 25.6 | 7.3 | 0.006 | | Weight (kg) | 67.8 | 12.3 | 67.0 | 43–140 | 66.1 | 10.8 | 69.3 | 13.3 | 0.062 | | BMI (kg/m2) | 23.1 | 3.0 | 22.6 | 16.7–40.9 | 22.8 | 2.8 | 23.3 | 3.1 | 0.213 | | T1DM duration (years) | 13.3 | 6.4 | 13.0 | 2–37 | 13.2 | 6.7 | 13.5 | 6.2 | 0.479 | | Duration of CSII use (years) | 6.8 | 3.6 | 7.0 | 1–17 | 6.4 | 3.7 | 7.1 | 3.5 | 0.091 | | HbA1c (%) | 7.4 | 1.2 | 7.2 | 5.16–11.7 | — | — | — | — | — | | %BI (%) | 42.1 | 10.1 | 42.0 | 14–78 | 39.4 | 9.7 | 44.5 | 10.0 | 0.000 | | DID (IU) | 47.8 | 15.7 | 45.5 | 9–110 | 44.7 | 15.3 | 50.5 | 15.7 | 0.002 | | DID/kg (IU/kg) | 0.71 | 0.20 | 0.69 | 0.11–1.62 | 0.68 | 0.21 | 0.73 | 0.19 | 0.016 | | Average glycemia from glucose meter (mg/dl) | 157.3 | 34.0 | 155.0 | 88–279 | 143.4 | 28.8 | 169.2 | 33.7 | 0.000 | | Number of glucometer measurements per day (n) | 5.4 | 3.0 | 5.0 | 0.2–15.5 | 6.1 | 3.2 | 4.7 | 2.6 | 0.010 |
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BMI, body mass index; DID, daily insulin dose; CSII, continuous subcutaneous insulin infusion; %BI, percentage of basal insulin; IU, insulin units.
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