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Advances in Materials Science and Engineering
Volume 2013, Article ID 128271, 6 pages
Research Article

Study of the Boson Peak and Fragility of Bioprotectant Glass-Forming Mixtures by Neutron Scattering

1Department of Physics and Earth Sciences, University of Messina, Viale D’Alcontres 31, P.O. Box 55, 98166 Messina, Italy
2Institut Laue Langevin, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France
3CNR-IOM-OGG, Institut Laue Langevin, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France

Received 31 May 2013; Accepted 23 August 2013

Academic Editor: Gerhard Schumacher

Copyright © 2013 F. Migliardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The biological relevance of trehalose, glycerol, and their mixtures in several anhydrobiotic and cryobiotic organisms has recently promoted both experimental and simulation studies. In addition, these systems are employed in different industrial fields, such as pharmaceutical and cosmetic industries, as additives in mixtures for cryopreservation and in several formulations. This review article shows an overview of Inelastic Neutron Scattering (INS) data, collected at different temperature values by the OSIRIS time-of-flight spectrometer at the ISIS Facility (Rutherford Appleton Laboratory, Oxford, UK) and by the IN4 and IN6 spectrometers at the Institut Laue Langevin (ILL, Grenoble, France), on trehalose/glycerol mixtures as a function of the glycerol content. The data analysis allows determining the Boson peak behavior and discussing the findings in terms of fragility in relation to the bioprotective action of trehalose and glycerol.