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Advances in Materials Science and Engineering
Volume 2013 (2013), Article ID 328763, 8 pages
Research Article

Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization

1Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China
2School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China

Received 14 March 2013; Revised 29 May 2013; Accepted 31 May 2013

Academic Editor: Delia Brauer

Copyright © 2013 Eltjani-Eltahir Hago and Xinsong Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.