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Advances in Materials Science and Engineering
Volume 2015 (2015), Article ID 306708, 8 pages
http://dx.doi.org/10.1155/2015/306708
Research Article

A Turbidity Test Based Centrifugal Microfluidics Diagnostic System for Simultaneous Detection of HBV, HCV, and CMV

1Department of Mechanical Engineering, National Taiwan University, Taipei 106, Taiwan
2College of Medicine, National Taiwan University, Taipei 106, Taiwan
3Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan
4Department of Aerospace and System Engineering, Feng Chia University, Taichung 407, Taiwan
5Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan
6Department of Electronic Engineering, National Taiwan University, Taipei 106, Taiwan

Received 2 October 2014; Accepted 24 November 2014

Academic Editor: Timo Sajavaara

Copyright © 2015 Hung-Cheng Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper presents a LAMP- (loop-mediated isothermal amplification-) based lab-on-disk optical system that allows the simultaneous detection of hepatitis B virus, hepatitis C virus, and cytomegalovirus. The various flow stages are controlled in the proposed system using different balance among centrifugal pumping, Coriolis pumping, and the capillary force. We have implemented a servo system for positioning and speed control for the heating and centrifugal pumping. We have also successfully employed a polymer light-emitting diode section for turbidity detection. The easy-to-use one-click system can perform diagnostics in less than 1 hour.