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Advances in Materials Science and Engineering
Volume 2016, Article ID 3452171, 5 pages
Research Article

Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration

1Faculty of Veterinary Medicine, Banat’s University of Agricultural Sciences, 119 Calea Aradului, 300645 Timişoara, Romania
2Collagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, Romania
3Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy “Victor Babes”, Piata Eftimie Murgu 2, 300041 Timişoara, Romania
4Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania

Received 4 February 2016; Accepted 3 March 2016

Academic Editor: Mikhael Bechelany

Copyright © 2016 Narcisa Mederle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bone regeneration is a serious challenge in orthopedic applications because of bone infections increase, tumor developing, and bone loss due to trauma. In this context, the aim of our study was to develop innovative biomaterials based on collagen and hydroxyapatite (25, 50, and 75%) which mimic bone composition and prevent or treat infections due to doxycycline content. The biomaterials were obtained by freeze-drying in spongious forms and were characterized by water uptake capacity and microscopy. The in vitro release of doxycycline was also determined and established by non-Fickian drug transport mechanism. Among the studied biomaterials, the most suitable one to easily deliver the drug and mimic bone structure, having compact structure and lower capacity to uptake water, was the one with 75% hydroxyapatite and being cross-linked.