Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions

Table 4

Release constants, correlation coefficients, and MSC obtained by fitting the release profiles of desonide using dialysis sac, according to the monoexponential and biexponential equations.

Equation	D-LNC	D-NC-S100	D-NC-L100	Free-desonide
Monoexponential
(h^−1)	0.34 ± 0.12	0.45 ± 0.06	0.6 ± 0.08	0.25 ± 0.01
(h)	2.06 ± 0.40	1.70 ± 0.20	1.16 ± 0.16	2.36 ± 0.95
MSC	4.68 ± 0.82	4.55 ± 0.73	4.94 ± 0.47	4.51 ± 0.66
	0.998 ± 0.007	0.996 ± 0.004	0.998 ± 0.001	0.995 ± 0.002
Biexponential
	0.41 ± 0.09	0.68 ± 0.09	0.58 ± 0.07	0.52 ± 0.15
(h^−1)	1.54 ± 0.20	1.31 ± 0.10	1.62 ± 0.45	1.28 ± 0.67
b	0.59 ± 0.07	0.31 ± 0.05	0.41 ± 0.03	0.46 ± 0.22
(h^−1)	0.88 ± 0.03	0.03 ± 0.01	0.05 ± 0.01	0.06 ± 0.03
MSC	3.29 ± 0.05	4.51 ± 0.30	4.18 ± 0.77	4.41 ± 0.25
	0.991 ± 0.006	0.995 ± 0.004	0.997 ± 0.001	0.993 ± 0.004

Experiments were conducted with .