A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling

Figure 1

Representative histological images of the implantation site at 4 ((a), (c), and (e)) and 12 ((b), (d), and (f)) weeks from surgery. Bone was stained with Toluidine Blue, Acid Fuchsin, and Fast Green. The low magnification images reported in (a) and (b) allows distinguishing the bone area where nanoindentation has been carried out onto novel () and native (#) tissue. Scale bar is 5 mm in (a) and (b) whereas it is 1 mm in (c–f). The newly formed bone as well as native bone is stained in light blue; brownish material is the residual macroporous HA scaffold.

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