Production and use of composites have increased with the development of science and technology. Polymer composites are among the most widely employed materials in medicine. In polymer matrix composites, a matrix is a polymeric material. The second phase dispersed in the matrix is the reinforcement phase in scale dimensions. The small size of the reinforcement phase ensures that the interface-to-volume ratio of composites is significantly higher compared to conventional composites (e.g., microcomposites). There are significant changes in mechanical properties within the transition from nano to macroparticles. Scale materials have a large surface area. The structured materials may show different properties even if they are in the same composition as structured materials since chemical and physical properties are controlled by surface properties.

Technological progress over the last two decades in the biomaterial field has enabled developments in the materials-based health care industry. These technological developments have improved our quality of life. It has resulted in the production of more efficient and sophisticated medical devices available in the market today. Meanwhile, material science and technology and their extensive applications have developed in research fields worldwide since materials possess new and unique properties. From the various methods for the synthesis of materials, green approaches by using natural materials are widely adopted in biomedical fields to avoid organic passivates which are hazardous both for the environment and the human body. These materials such as metal/metal oxide compounds, polymers, and their composites widely used in tissue engineering (e.g., bone regeneration, wound healing, wound dressing, drug delivery, nerve regeneration, etc.), bio-sensing, cancer, drug delivery, and microneedles patches. The unique properties of materials have revealed a strong potential for the rapid development of technology-based biomedical applications. There are already some materials-based products available in the market and many are in the pipeline for commercialization. Over the last decade, many studies have been devoted to creating green materials that possess biological activities for various medicinal applications.

The aim of this Special Issue is to bring together original research and review articles discussing the use of biosynthesized materials and their biocomposites for various biomedical applications. We welcome submissions including biomedical applications such as dental composites, tissue engineering, drug delivery, biosensors, microneedles patches, and photothermal therapy.

Potential topics include but are not limited to the following:

• Green synthesis of different sized materials with biological activity
• Biocomposites for regenerative medicine
• Biosynthesized materials for cancer therapy
• Materials for bio-sensing
• Materials for microneedles patches
• Materials for targeted delivery
• Materials for wound healing and wound dressing
• Microorganism mediated synthesis
• Functionalization/decoration for infection therapy
• Plant-mediated synthesis