Table of Contents
Advances in Nephrology
Volume 2014, Article ID 516381, 8 pages
Review Article

Managing End-Stage Renal Disease in Older Patients: A Single Centre Experience with Renal Transplantation in the Elderly

1Section of Nephrology, Department of Organ Transplantation, Oslo University Hospital Rikshospitalet, 0424 Oslo, Norway
2Clinic of Internal Medicine, Telemark Hospital, 3710 Skien, Norway
3Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway

Received 12 December 2013; Revised 24 February 2014; Accepted 24 February 2014; Published 25 March 2014

Academic Editor: Francois Madore

Copyright © 2014 Karsten Midtvedt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The increase of patients developing end-stage renal disease (ESRD) has occurred predominantly in the older adult population. As a consequence, the nephrologists will need to decide whom of these older patients are siutable for transplantation. There are very few absolute contraindications, such as active infection and recent malignancy, but there are many relative or potential contraindications in older patients. Worldwide, organs available for transplantation are limited. Some centers are reluctant to use organs from expanded criteria donors also in elderly recipients. This leads to long waiting lists and many older patients will die while they are waiting for an organ. It is vital that the patients who are accepted for renal transplantation are those who will derive most benefit, and correct selection of patients and donor organs is therefore of outmost importance. This paper describes the previous and planned research our research group has performed with focus on older renal transplant recipients with special emphasis on survival, basic immunosuppression, selection of organs, and health related quality of life.