Table of Contents
Advances in Nephrology
Volume 2014, Article ID 701487, 5 pages
Research Article

Moderately Decreased Dietary Salt Intake Suppresses the Progression of Renal Insufficiency in Rats with 5/6 Nephrectomy

1Department of Transplantation and Tissue Banking, University Hospital Motol, 150 06 Prague, Czech Republic
2Charles University 2nd School of Medicine, 150 06 Prague, Czech Republic
3Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
4Department of Cardiology, Charles University School of Medicine, 304 60 Plzen, Czech Republic
5Department of Medicine, Charles University 2nd School of Medicine and University Hospital Motol, 150 06 Prague, Czech Republic

Received 1 July 2014; Revised 8 September 2014; Accepted 11 October 2014; Published 10 November 2014

Academic Editor: Jane Black

Copyright © 2014 Jan Burkert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Up to now, an appropriate salt intake in renal insufficiency has not been clearly determined. We hypothesize that even a moderate decrease in salt intake may affect functional and morphologic response of the rat remnant kidney after 5/6 nephrectomy. Methods. Subtotal nephrectomy was performed in 77 inbred 12 week-old-female AVN Wistar rats. The two groups of rats were fed either a standard or a low salt diet. Median of salt intake was 14.6 and 10.4 mg/100 g/24 h in the two groups. Results. Ten weeks after ablation, the remnant kidney parenchyma wet weight was 0.66 ± 0.16 g/100 g of body weight and 0.56 ± 0.11 g/100 g of body weight () in rats with a standard and low salt diet, respectively. In these two groups, systolic blood pressure was 151 ± 29 versus 126 ± 21 mmHg (), serum creatinine levels were 164 ± 84 versus 106 ± 29 µmol/L (), proteinuria was 84 ± 37 versus 83 ± 40 mg/100 g/24 h (N.S.), and the glomerular injury score was 2.06 ± 0.49 versus 1.43 ± 0.62 (), respectively. Conclusion. Moderately decreased salt intake slowed down the development of ablation nephropathy in AVN inbred strain of rats.