TY - JOUR A2 - Musso, Carlos G. AU - Rocque, Brittany AU - Torban, Elena PY - 2015 DA - 2015/02/25 TI - Planar Cell Polarity Pathway in Kidney Development and Function SP - 764682 VL - 2015 AB - The evolutionarily conserved planar cell polarity (PCP) signaling pathway controls tissue polarity within the plane orthogonal to the apical-basal axis. PCP was originally discovered in Drosophila melanogaster where it is required for the establishment of a uniform pattern of cell structures and appendages. In vertebrates, including mammals, the PCP pathway has been adapted to control various morphogenetic processes that are critical for tissue and organ development. These include convergent extension (crucial for neural tube closure and cochlear duct development) and oriented cell division (needed for tubular elongation), ciliary tilting that enables directional fluid flow, and other processes. Recently, strong evidence has emerged to implicate the PCP pathway in vertebrate kidney development. In this review, we will describe the experimental data revealing the role of PCP signaling in nephrogenesis and kidney disease. SN - 2356-6779 UR - https://doi.org/10.1155/2015/764682 DO - 10.1155/2015/764682 JF - Advances in Nephrology PB - Hindawi Publishing Corporation KW - ER -