Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer
Figure 3
Intrafemoral gene transfer prevents MMC-induced BM aplasia. (a) FancC-EGFP transgene expression in peripheral blood cells of IF-injected wild type (WT), , and mice as a function of time. Each dot represents the FancC-EGFP expression of an individual IF-injected mouse. The arrow represents the start of weekly MMC injections (0.3 mg/kg). Horizontal line: mean value. . (b) Survival curves of IF-injected () and () mice following MMC treatments. Control mice represent uninjected mice treated weakly with MMC (). (c) Representative histological appearances of the sternum from injected mice after 15 weeks of MMC treatment. Hematoxylin-eosin staining: original magnification 200.
