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Volume 2011, Article ID 435683, 7 pages
Research Article

The Management of Iron Chelation Therapy: Preliminary Data from a National Registry of Thalassaemic Patients

1Consorzio per Valutazioni Biologiche e Farmacologiche, Via L. Porta 14, 27100 Pavia, Italy
2I.RI.D.I.A. srl, Viale Concilio Vaticano II 75/B, 70124 Bari, Italy
3U.S. Dipartimentale Ematologia-DH Talassemia, Ospedale “Madonna delle Grazie”, Via Montescagliaso C. da Cattedra Ambulante 1, 75100 Matera, Italy
4UOC Ematologia-Emoglobinopatie, Ospedale “G. Di Cristina”, Via Benedettini 1, 90100 Palermo, Italy
5Centro Microcitemia, Azienda Ospedaliera “Bianchi Melacrino Morelli”, Via Melacrino 1, 89126 Reggio Calabria, Italy
6U.O. Day Hospital Talassemia, Ospedale “S. Eugenio”, Piazzale Umanesimo 10, 00144 Roma, Italy
7UOS Talassemia Pediatrica ed Emoglobinopatie Pediatriche, Azienda Ospedaliera di Rilievo Nazionale “Antonio Cardarelli”, Via A. Cardarelli 9, 80131 Napoli, Italy

Received 14 January 2011; Revised 28 March 2011; Accepted 11 April 2011

Academic Editor: Yurdanur Kilinç

Copyright © 2011 Adriana Ceci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thalassaemia and other haemoglobinopathies constitute an important health problem in Mediterranean countries, placing a tremendous emotional, psychological, and economic burden on their National Health systems. The development of new chelators in the most recent years had a major impact on the treatment of thalassaemia and on the quality of life of thalassaemic patients. A new initiative was promoted by the Italian Ministry of Health, establishing a Registry for thalassaemic patients to serve as a tool for the development of cost-effective diagnostic and therapeutic approaches and for the definition of guidelines supporting the most appropriate management of the iron-chelating therapy and a correct use of the available iron-chelating agents. This study represents the analysis of the preliminary data collected for the evaluation of current status of the iron chelation practice in the Italian thalassaemic population and describes how therapeutic interventions can widely differ in the different patients' age groups.