Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease

Table 1

Subject characteristics and hematologic parameters. There was no difference in age and sex of the participants in each group. Hemoglobin SS subjects had significantly lower hemoglobin concentration and higher WBC and platelet counts (indicated by asterisks (*)).

	Control			Hemoglobin SS			𝑃 value
	𝑛	Arithmetic mean (95th% CI)	Geometric mean (95th% CI)	𝑛	Arithmetic mean (95th% CI)	Geometric mean (95th% CI)
Age (yrs)	68	12.8 (12–13.8)	12.3 (11.4–13.3)	43	12 (11–13)	11.5 (10.4–12.6)	0.26
Sex (males)	68	30 (44%)		43	20 (47%)
Hemoglobin (gm/dL)	39	13.6 (12.1–15.2)	13.2 (12.4–14.1)	19	8.4 (7.8–9)	8.3* (7.7–8.9)	<0.001
WBC (×10^3/mL)	39	5.4 (4.9–6)	5.2 (4.7–5.7)	18	12.1 (9.6–14.4)	11.4* (9.7–13.4)	<0.001
Platelets (×10^3/mL)	39	280 (261–298)	274 (257–293)	18	413 (373–454)	406* (368–448)	<0.001