Research Article

Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical Trial

Table 2

Mean (SD) SF-36 domain and summary scores among MDS patients according to prior ICT history.

Baseline mean (SD)EOS mean (SD)
Reference MDS population
( ): mean (SD)
Age-matched UK norms: mean (SD)Prior ICT ( –62)ICT Naïve ( -35)Prior ICT ( –40)ICT Naïve ( –35)

Physical functioning48.177.4253.6044.5647.4348.79
(30.6)(25.38)(21.35)(17.94)(24.39)(23.29)
Role-physical39.278.1636.3926.4330.2129.66
(42.5)(28.11)(39.21)(36.85)(40.90)(35.60)
Bodily pain66.671.5265.6164.6963.2359.77
(31.2)(26.46)(27.43)(27.16)(28.53)(31.85)
General health41.566.2442.7040.7237.7841.55
(21.3)(22.57)(18.94)(20.00)(20.01)(15.92)
Vitality50.657.7943.2537.3542.8940.20
(25.3)(21.28)(19.02)(15.92)(24.10)(16.81)
Social functioning67.081.0868.5571.0762.1863.21
(29.6)(26.14)(29.75)(23.24)(25.57)(21.21)
Role-emotional59.084.1157.1861.9041.2351.96
(41.4)(24.41)(44.05)(41.34)(43.45)(45.83)
Mental health72.373.8466.7869.0660.0764.47
(20.9)(19.35)(22.34)(18.54)(22.85)(23.01)
Physical component summary35.744.4736.9733.1036.2135.11
(11.7)(12.32)(8.48)(8.31)(8.70)(10.80)
Mental component summary48.952.2846.3248.4942.1445.27
(12.6)(9.89)(12.02)(10.04)(11.61)(11.97)

Transfusion-dependent MDS patient reference data reported by Jansen et al. [17]; UK norms from Jenkinson et al. [42] and direct email communications from Dr. Jenkinson on Oct 24, 2011 with age-specific norms.