Review Article

Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics

Table 2

ATM-deficiency in cancer.

MalignancyATM-deficient cell lines/number tested

T-cell prolymphocytic leukemia [73]17/32
Mantle cell lymphoma [53]12/28
Rhabdomyosarcoma [74]7/17
Chronic lymphoblastic leukemia [54, 73]16/50, 38/111
BRCA1-negative breast cancer [75]12/36
BRCA2 negative breast cancer [75]12/40
Acute lymphoblastic leukemia [54]4/15
Non-BRCA1/BRCA2 negative breast cancers [75]118/1106
Other lymphomas [53]10/97