Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

Figure 2

Weight and liver cell morphology of mice with distinct levels of Ercc1 activity. ((a)–(c)) Mean body weight of (a) 3-week-old Ercc1^−/− (𝑛=6), Ercc1^−/d (𝑛=7), Ercc1^d/d (𝑛=4), and wt (𝑛=13) mice. (b) 10-week-old Ercc1^d/d (𝑛=3), Ercc1^−/d (𝑛=3), and wt (𝑛=6) mice. (c) 20-week-old Ercc1^-/d (𝑛=8), Ercc1^d/d (𝑛=5), and wt (𝑛=12) mice. (d) Hematoxylin- and eosin-stained sections of liver from 3-week-old wt, Ercc1^−/−, Ercc1^−/d, and Ercc1^d/d mice. (e) Quantification of enlarged nuclei (>8 μm). Error bars indicate standard deviation. *indicates 𝑃≤0.05, **indicates 𝑃≤0.01, and ***indicates 𝑃≤0.001.

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