Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

Figure 4

Colony-forming potential of bone marrow progenitors is affected in hypomorphic models or Ercc1. BFU-E, CFU-G, and CFU-GM colonies per 5×104 bone marrow cells derived from ((a)–(c)) 3-week-old Ercc1^−/− (𝑛=6), Ercc1^−/d (𝑛=7), Ercc1^d/d (𝑛=4), and wt mice (𝑛=7) ((d)–(f)) 10-week-old Ercc1^−/d (𝑛=3), Ercc1^d/d (𝑛=3), and wt mice (𝑛=3), ((g)–(i)) 20-week-old Ercc1^−/d (𝑛=3), Ercc1^d/d (𝑛=6), and wt mice (𝑛=8). Error bars indicate standard deviation. *indicates 𝑃≤0.05, **indicates 𝑃≤0.01, and ***indicates 𝑃≤0.001.