Research Article
Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values
Table 1
Characteristics of alloimmunized pregnancies included in the study.
| | Gestational and perinatal characteristics | | Values | Variation or % |
| | Maternal age, years (mean ± SD) | 105 | | 19 to 43 | | Parity (median, range) | 105 | 4 | 1 to 11 | | Anti-D antibodies (alone), (%) | 99 | 54 | 54.5% | | Anti-D + anti-C antibodies, (%) | 99 | 32 | 32.5% | | GA, weeks, at first cordocentesis (mean ± SD) | 105 | | 19 to 34 | | Fetal hemoglobin (g/dL), at first cordocentesis (mean ± SD) | 105 | | 2.2 to 16.4 | | Fetal severe anemia (>7.0 g/dL hemoglobin deficit)*, (%) | 105 | 24 | 22.9% | | Fetal severe anemia (≥5.0 g/dL hemoglobin deficit)**, (%) | 105 | 41 | 39.1% | | Fetal severe anemia (hemoglobin < 0.55 MoM***, (%) | 105 | 30 | 28.6% | | Fetal pH, at first cordocentesis (median, range) | 101 | 7.35 | 7.07–7.49 | | Fetal hydrops at first cordocentesis, (%) | 105 | 26 | 24.8% | | Perinatal mortality, (%) | 105 | 20 | 19.1% | | Apgar 5 (median, range) | 89 | 9 | 2 to 10 |
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Nicolaides et al. [11], **Bahado-Singh et al. [12], and ***Mari et al. [10]; SD: standard deviation, GA: gestational age.
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