Research Article

Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values

Table 2

Perinatal outcome, according to concordance in classifying anemia severity using the several criteria analyzed.

Concordant nonsevere anemia cases Discordant severe anemia cases Concordant severe anemia cases

hb ≥ 5.0 g/dL deficit [12] versus hb < 0.55 MoM [10]( )( )( )

Fetal pH#1017.39 (7.10–7.49)7.33 (7.19–7.43)7.35 (7.07–7.45)0.076*
Fetal hydrops+1058 (12.5%)2 (20%)16 (51.6%)<0.001**
Perinatal death1055 (7.8%)3 (30%)12 (38.7%)0.001**
Apgar 5899 (2–10)9 (9-9)9 (2–10)0.603*

hb > 7.0 g/dL deficit [11] versus hb ≥ 5.0 g/dL deficit [12] ( )( )( )

Fetal pH#1017.39 (7.10–7.49)7.34 (7.19–7.46)7.34 (7.07–7.45)0.069*
Fetal hydrops+1058 (12.5%)6 (33.3%)12 (52.2%)0.001**
Perinatal death1055 (7.8%)5 (27.8%)10 (43.5%)0.001**
Apgar 5 899 (2–10)9 (9-9)9 (2–10)0.318*

hb > 7.0 g/dL deficit [11] versus hb < 0.55 MoM [10]( )( )( )

Fetal pH#1017.38 (7.10–7.49)7.37 (7.30–7.43)7.34 (7.07–7.45)0.172*
Fetal hydrops+10510 (13.5%)4 (50%)12 (52.2%)<0.001**
Perinatal death1058 (10.8%)2 (25%)10 (43.5%)0.002**
Apgar 5 899 (2–10)9 (9-9)9 (2–10)0.539*

Note: 1st cordocentesis, *Kruskal-Wallis test, **Chi-square test, hb: foetal hemoglobin value at first cordocentesis.