Research Article
Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values
Table 2
Perinatal outcome, according to concordance in classifying anemia severity using the several criteria analyzed.
| | | Concordant nonsevere anemia cases | Discordant severe anemia cases | Concordant severe anemia cases | |
| hb ≥ 5.0 g/dL deficit [12] versus hb < 0.55 MoM [10] | () | () | () | |
| Fetal pH# | 101 | 7.39 (7.10–7.49) | 7.33 (7.19–7.43) | 7.35 (7.07–7.45) | 0.076* | Fetal hydrops+ | 105 | 8 (12.5%) | 2 (20%) | 16 (51.6%) | <0.001** | Perinatal death | 105 | 5 (7.8%) | 3 (30%) | 12 (38.7%) | 0.001** | Apgar 5 | 89 | 9 (2–10) | 9 (9-9) | 9 (2–10) | 0.603* |
|
hb > 7.0 g/dL deficit [11] versus hb ≥ 5.0 g/dL deficit [12] | () | () | () | |
| Fetal pH# | 101 | 7.39 (7.10–7.49) | 7.34 (7.19–7.46) | 7.34 (7.07–7.45) | 0.069* | Fetal hydrops+ | 105 | 8 (12.5%) | 6 (33.3%) | 12 (52.2%) | 0.001** | Perinatal death | 105 | 5 (7.8%) | 5 (27.8%) | 10 (43.5%) | 0.001** | Apgar 5 | 89 | 9 (2–10) | 9 (9-9) | 9 (2–10) | 0.318* |
|
hb > 7.0 g/dL deficit [11] versus hb < 0.55 MoM [10] | () | () | () | |
| Fetal pH# | 101 | 7.38 (7.10–7.49) | 7.37 (7.30–7.43) | 7.34 (7.07–7.45) | 0.172* | Fetal hydrops+ | 105 | 10 (13.5%) | 4 (50%) | 12 (52.2%) | <0.001** | Perinatal death | 105 | 8 (10.8%) | 2 (25%) | 10 (43.5%) | 0.002** | Apgar 5 | 89 | 9 (2–10) | 9 (9-9) | 9 (2–10) | 0.539* |
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Note: 1st cordocentesis, *Kruskal-Wallis test, **Chi-square test, hb: foetal hemoglobin value at first cordocentesis.
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