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Anemia
Volume 2014, Article ID 125452, 6 pages
http://dx.doi.org/10.1155/2014/125452
Research Article

Assessment of Serum Zinc Levels of Patients with Thalassemia Compared to Their Siblings

1Cure2Children Foundation, Via Marconi 30, 50131 Florence, Italy
2Children’s Hospital Pakistan Institute of Medical Sciences, Islamabad, Pakistan

Received 31 January 2014; Accepted 5 August 2014; Published 14 August 2014

Academic Editor: Aurelio Maggio

Copyright © 2014 Mohamed El Missiry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Hirano, M. Murakami, T. Fukada, K. Nishida, S. Yamasaki, and T. Suzuki, “Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule,” Advances in Immunology, vol. 97, pp. 149–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. S. MacDonald, “The role of zinc in growth and cell proliferation,” Journal of Nutrition, vol. 130, pp. 1500S–1508S, 2000. View at Google Scholar · View at Scopus
  3. J. Brandão-Neto, V. Stefan, B. B. Mendonça, W. Bloise, and A. V. B. Castro, “The essential role of zinc in growth,” Nutrition Research, vol. 15, pp. 335–358, 1995. View at Google Scholar
  4. M. Yu, W.-W. Lee, D. Tomar et al., “Regulation of T cell receptor signaling by activation-induced zinc influx,” The Journal of Experimental Medicine, vol. 208, no. 4, pp. 775–785, 2011. View at Publisher · View at Google Scholar
  5. J. L. Kadrmas and M. C. Beckerle, “The LIM domain: from the cytoskeleton to the nucleus,” Nature Reviews Molecular Cell Biology, vol. 5, no. 11, pp. 920–931, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Moshtaghi-Kashanian, A. Gholamhoseinian, A. Hoseinimoghadam, and S. Rajabalian, “Splenectomy changes the pattern of cytokine production in β-thalassemic patients,” Cytokine, vol. 35, no. 5-6, pp. 253–257, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Mehdizadeh, G. Zamani, and S. Tabatabaee, “Zinc status in patients with major β-thalassemia,” Pediatric Hematology and Oncology, vol. 25, no. 1, pp. 49–54, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. P. J. Fraker and L. E. King, “Reprogramming of the immune system during zinc deficiency,” Annual Review of Nutrition, vol. 24, pp. 277–298, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Y. Yakoob, E. Theodoratou, A. Jabeen et al., “Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria,” BMC Public Health, vol. 11, no. 3, article S23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. R. S. Gibson and E. L. Ferguson, “Nutrition intervention strategies to combat zinc deficiency in developing countries,” Nutrition Research Reviews, vol. 11, no. 1, pp. 115–131, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. O. Donma, S. Gunbey, and M. A. M. M. tas Donma, “Zinc, copper, and magnesium concentrations in hair of children from southeastern Turkey,” Biological Trace Element Research, vol. 24, no. 1, pp. 39–47, 1990. View at Google Scholar · View at Scopus
  12. F. Rea, L. Perrone, A. Mastrobuono, G. Toscano, and M. D'Amico, “Zinc levels of serum, hair and urine in homozygous beta-thalassemic subjects under hypertransfusional treatment,” Acta Haematologica, vol. 71, no. 2, pp. 139–142, 1984. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Galanello, “Deferiprone in the treatment of transfusion-dependent thalassemia: a review and perspective,” Therapeutics and Clinical Risk Management, vol. 3, no. 5, pp. 795–805, 2007. View at Google Scholar · View at Scopus
  14. M. D. Cappellini, “Exjade (deferasirox, ICL670) in the treatment of chronic iron overload associated with blood transfusion,” Therapeutics and Clinical Risk Management, vol. 3, no. 2, pp. 291–299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Hambidge, “Human zinc deficiency,” Journal of Nutrition, vol. 130, no. 5, pp. 1344S–1349S, 2000. View at Google Scholar · View at Scopus
  16. G. J. Fuchs, P. Tienboon, S. Linpisarn et al., “Nutritional factors and thalassaemia major,” Archives of Disease in Childhood, vol. 74, no. 3, pp. 224–227, 1996. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Kyriakou and N. Skordis, “Thalassaemia and aberrations of growth and puberty,” Mediterranean Journal of Hematology and Infectious Diseases, vol. 1, no. 1, 2009. View at Google Scholar
  18. V. de Sanctis, A. Eleftheriou, and C. Malaventura, “Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF),” Pediatric Endocrinology Reviews, vol. 2, supplement 2, pp. 249–255, 2004. View at Google Scholar · View at Scopus
  19. C. Theodoridis, V. Ladis, A. Papatheodorou et al., “Growth and management of short stature in thalassaemia major,” Journal of Pediatric Endocrinology and Metabolism, vol. 11, no. 3, pp. 835–844, 1998. View at Google Scholar · View at Scopus
  20. Guidelines for the clinical management of thalassemia, 2008.
  21. A. Mahyar, P. Ayazi, A. A. Pahlevan, H. Mojabi, M. R. Sehhat, and A. Javadi, “Zinc & copper status in children with Beta-thalassemia major,” Iranian Journal of Pediatrics, vol. 20, pp. 297–302, 2010. View at Google Scholar