Research Article
Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients
Table 2
Liver enzyme and cardiac function parameters stratified by serum ferritin level classification.
| | | Serum ferritin (ng/mL) | | <2500 (n = 22) | 2500–5000 (n = 20) | >5000 (n = 24) | value |
| | Liver enzymes, ng/mL (mean ± SD) | | AST | 44.8 ± 21.9 | 54.6 ± 2.0 | 65.3 ± 35.9 | 0.066 | | ALT | 37.5 ± 19.3 | 50.5 ± 25.5 | 60.9 ± 43.6 | 0.051 | | Cardiac function parameters (mean ± SD) | | Echocardiography | | | | | | LVPWDD (mm) | 9.0 ± 1.9 | 8.8 ± 1.5 | 7.7 ± 1.1 | 0.017 | | LVPWSD (mm) | 13.6 ± 1.8 | 14.8 ± 4.5 | 13.5 ± 2.7 | 0.312 | | LVEDV (mL) | 145.5 ± 14.3 | 96.0 ± 21.5 | 88.8 ± 19.0 | 0.066 | | LVESV (mL) | 36.8 ± 11.5 | 32.8 ± 9.7 | 31.5 ± 10.7 | 0.221 | | LVSV (mL) | 66.4 ± 14.2 | 63.1 ± 13.3 | 57.3 ± 10.2 | 0.054 | | LVEF (%) | 64.7 ± 4.8 | 66.3 ± 4.5 | 65.2 ± 5.2 | 0.552 | | LVFS (%) | 35.4 ± 3.9 | 36.6 ± 3.3 | 35.6 ± 3.9 | 0.580 | | LV diastolic function E/A ratio (m/s) | 1.6 ± 0.4 | 1.6 ± 0.3 | 1.6 ± 0.3 | 0.886 | | LV diastolic function DT (ms) | 168.0 ± 43.3 | 155.5 ± 27.2 | 154.0 ± 25.6 | 0.304 | | LV diastolic function E/E′ | 9.7 ± 2.7 | 13.5 ± 18.5 | 12.4 ± 13.1 | 0.636 | | LV diastolic function IVRT (ms) | 70.5 ± 8.9 | 71.3 ± 5.1 | 64.5 ± 17.2 | 0.262 | | LV diastolic function LAVI (mL/m2) | 33.9 ± 17.3 | 28.2 ± 5.4 | 27.3 ± 6.8 | 0.130 | | Mean PA pressure (mmHg) | 18.6 ± 10.1 | 18.6 ± 8.3 | 20.2 ± 8.5 | 0.799 | | TAPSE (mm) | 24.0 ± 3.8 | 23.4 ± 2.8 | 21.1 ± 2.9 | 0.011 | | Electrocardiography, n (%) | | | | 0.958 | | Normal | 11 (52.4) | 8 (44.4) | 10 (41.7) | | | Tachycardia | 2 (9.5) | 0 (0.0) | 4 (16.7) | | | T-wave inversion | 3 (14.3) | 10 (55.6) | 7 (29.2) | | | Left ventricular hypertrophy | 2 (9.5) | 0 (0.0) | 2 (8.3) | | | RBBB | 2 (9.5) | 0 (0.0) | 0 (0.0) | | | Arrhythmia | 1 (4.8) | 0 (0.0) | 0 (0.0) | | | Supraventricular extra systole | 0 (0.0) | 0 (0.0) | 1 (4.2) | |
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< 0.05 compared with serum ferritin <2500, AST: aspartate aminotransferase; ALT: alanine aminotransferase; LVPWDD: left ventricular posterior wall diastolic diameter; LVPWSD: left ventricular posterior wall systolic diameter; LVEDV: left ventricular end-diastolic volume; LVESV: left ventricular end-systolic volume; LVSV: left ventricular stroke volume; LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; LV: left ventricle; DT: deceleration time; IVRT: isovolumic (or isovolumetric) relaxation time; LAVI: left atrial volume index; PA: pulmonary artery; TAPSE: tricuspid annular plane systolic excursion; RBBB: right bundle branch block. |
