Review Article
Rett Syndrome: Coming to Terms with Treatment
Table 5
Rett syndrome animal models of Rett syndrome.
| Mouse model type | Genetic composition | Reference |
| Null mutation | Tm1.1Bird | Exon 3-4 deletion | [139] | Tml1.1Jae | Exon 3 deletion | [140] | Tm1.Pplt | Methyl-binding domain deletion | [141] | 2loxB TH-Cre | Dopaminergic/noradrenergic neurons | [142] | 2loxB PET1-Cre | Serotonergic neurons | [143] | 2loxJ hGFAP-CreT2 | Astrocytes | [144] |
| Truncated mutation | Tm1Hzo | Nucleotide 308 truncation | [145] |
| Human point mutation | Tm1.1Coyle | R168X | [146] | Tm1.1Vnar | A140V | [147] | Tm1.1Hup | R168X | [148] | Tm1.1Joez | T158A | [149] | Tm1.1IRSF | R255X | Unpublished |
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