Table of Contents
Advances in Neuroscience
Volume 2014, Article ID 597395, 19 pages
Review Article

Reelin in the Years: Controlling Neuronal Migration and Maturation in the Mammalian Brain

Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

Received 18 August 2013; Accepted 15 October 2013; Published 5 January 2014

Academic Editor: Abdallah Hayar

Copyright © 2014 Gabriella D'Arcangelo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The extracellular protein Reelin was initially identified as an essential factor in the control of neuronal migration and layer formation in the developing mammalian brain. In the years following its discovery, however, it became clear that Reelin is a multifunctional protein that controls not only the positioning of neurons in the developing brain, but also their growth, maturation, and synaptic activity in the adult brain. In this review, we will highlight the major discoveries of the biological activities of Reelin and the underlying molecular mechanisms that affect the development and function of the mammalian brain, from embryonic ages to adulthood.